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Methotrexate

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Methotrexate tablets are used alone or together with other medicines to treat several types of cancer such as breast, head and neck, lung, blood, bone,… Read more

Brand names include: Rheumatrex Dose Pack, Trexall

By injection

Methotrexate injection is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood, bone,… Read more

Brand names include: Methotrexate Novaplus, Otrexup

Drug classes About this
Antineoplastic Agent, Antipsoriatic, Antirheumatic, Antirheumatic, Cytotoxic

What works? Research summarized

Evidence reviews

Methotrexate alone versus methotrexate in combination with other medications for rheumatoid arthritis

This summary of a Cochrane review presents what we know from research about the effect of methotrexate in combination with other drugs compared to methotrexate alone for rheumatoid arthritis (RA).

Methotrexate for juvenile idiopathic arthritis

Methotrexate (MTX) is a commonly used immuno modifying drug for children with juvenile arthritis. It is believed that MTX is an effective medication for children with juvenile arthritis. We reviewed the existing literature on the efficacy of MTX on patient centered disability measures. Two trials were found and the results were pooled. We found small to moderate effects of MTX. These effects ranged from 3 to 23% greater improvement in the MTX group than the placebo group. However, most of these effects were too small to be clinically significant.

The use of methotrexate, an immunomodulator drug, for treating people with multiple sclerosis

Multiple sclerosis (MS) is an immune disease of the nervous system. Drugs that interfere with the immune system, such as methotrexate could benefit people with the disease. To date research suggest that there may be small improvements from treatment with methotrexate. However, until these improvements need to be balanced against methotrexate's potentially serious side‐effects. Until larger research studies are performed, it will be too early to say whether the benefits of this drug outweigh its side‐effects.

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Summaries for consumers

Methotrexate alone versus methotrexate in combination with other medications for rheumatoid arthritis

This summary of a Cochrane review presents what we know from research about the effect of methotrexate in combination with other drugs compared to methotrexate alone for rheumatoid arthritis (RA).

Methotrexate for juvenile idiopathic arthritis

Methotrexate (MTX) is a commonly used immuno modifying drug for children with juvenile arthritis. It is believed that MTX is an effective medication for children with juvenile arthritis. We reviewed the existing literature on the efficacy of MTX on patient centered disability measures. Two trials were found and the results were pooled. We found small to moderate effects of MTX. These effects ranged from 3 to 23% greater improvement in the MTX group than the placebo group. However, most of these effects were too small to be clinically significant.

The use of methotrexate, an immunomodulator drug, for treating people with multiple sclerosis

Multiple sclerosis (MS) is an immune disease of the nervous system. Drugs that interfere with the immune system, such as methotrexate could benefit people with the disease. To date research suggest that there may be small improvements from treatment with methotrexate. However, until these improvements need to be balanced against methotrexate's potentially serious side‐effects. Until larger research studies are performed, it will be too early to say whether the benefits of this drug outweigh its side‐effects.

See all (97)

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