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Linezolid

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Linezolid is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia… Read more

Brand names include: Zyvox

By injection

Linezolid injection is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia… Read more

Brand names include: PremierPro Rx Zyvox, Zyvox

Drug classes About this
Antibiotic

What works? Research summarized

Evidence reviews

Linezolid versus vancomycin for gram-positive bacteraemia: a systematic review

Bibliographic details: Yue J R, Fang C L, Zhang X M, Dong B R.  Linezolid versus vancomycin for gram-positive bacteraemia: a systematic review . Chinese Journal of Evidence-Based Medicine 2009; 9(6): 646-651

Linezolid versus teicoplanin for MRSA pneumonia: a meta-analysis

Bibliographic details: Peng Y, Chen XF, Bi JQ, YAO ZJ.  Linezolid versus teicoplanin for MRSA pneumonia: a meta-analysis. Chinese Journal of Evidence-Based Medicine 2013; 13(11): 1340-1346 Available from: http://www.cjebm.org.cn/en/oa/DArticle.aspx?type=view&id=20131113

Effects and safety of linezolid vs vancomycin for the treatment of patients with MRSA: meta analysis of randomized controlled trials

Bibliographic details: Li Y, Tang HL, Hu YF, Peng FC.  Effects and safety of linezolid vs vancomycin for the treatment of patients with MRSA: meta analysis of randomized controlled trials. Chinese Pharmaceutical Journal 2011; 46(13): 1041-1046 Available from: http://www.zgyxzz.com.cn/EN/abstract/abstract27239.shtml

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Summaries for consumers

Antibiotic drugs for treating skin and soft tissue infections

Skin and soft tissue infections such as impetigo, abscesses, ulcers, and surgical site infections are common infections of the skin. For serious skin and soft tissue infections involving the deeper tissues, the death rate and treatment costs are high. Linezolid and vancomycin are antibiotics that are effective in treating skin and soft tissue infections, particularly infections caused by bacteria that have developed resistance to some antibiotics. This review identified nine RCTs, with a total of 3144 participants, and compared treatment with linezolid against treatment with vancomycin for skin and soft tissue infections. No new trials were identified for this first update. Linezolid was found to be more effective than vancomycin for treating these infections. There were fewer skin complications in the group that were treated with linezolid. There were no differences between the two groups in the number of reported deaths, and those treated with linezolid had shorter lengths of hospital stay than those treated with vancomycin. The daily cost of outpatient therapy was less with oral linezolid than with intravenous vancomycin, although for inpatient treatment, linezolid was more expensive than vancomycin. Well‐designed trials will be required in future to confirm these results, as the trials from which these conclusions were drawn were of poor methodological quality, at high risk of bias, and were funded by the pharmaceutical company that makes linezolid.

Antibiotic therapy for the treatment of methicillin‐resistant Staphylococcus aureus (MRSA) infections in people with surgical wounds

Some people having surgery develop wound infections. These are usually caused by bacteria. Most of these wound infections heal naturally, or after treatment with routine antibiotics . However, some bacteria are resistant to routine antibiotics, for example, methicillin‐resistant Staphylococcus aureus (MRSA). MRSA infection after surgery is rare, but can occur in wounds (surgical site infections, or SSIs), the chest, or bloodstream (bacteraemia). MRSA SSIs occur in 1% to 33% of people having surgery, depending on the type of surgery concerned; they can be life‐threatening and cause extended hospital stays.

Antibiotics to treat foot infections in people with diabetes

We reviewed the effects on resolution of infection and safety of antibiotics given orally or intravenously (directly into the blood system) in people with diabetes that have a foot infection.

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