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Furosemide

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Furosemide belongs to a group of medicines called loop diuretics (also known as water pills). Furosemide is given to help treat fluid retention (edema)… Read more

Brand names include: Active-Medicated Specimen Collection Kit, Diuscreen Multi-Drug Medicated Test Kit

By injection

Furosemide injection is used to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease (cirrhosis),… Read more

Brand names include: Furomide M.D., Furosemide Novaplus

Drug classes About this
Cardiovascular Agent

What works? Research summarized

Evidence reviews

Furosemide for prevention of morbidity in indomethacin‐treated infants with patent ductus arteriosus

There is no strong evidence of benefit from routine use furosemide, a loop diuretic, in preterm babies receiving indomethacin for treatment of patent ductus arteriosus. A blood vessel (ductus arteriosus), which is required for blood circulation for the fetus in the womb, closes soon after birth in babies born around the expected date of delivery (term infants). Babies born early (preterm) may develop symptoms if they do not close that blood vessel after birth. Preterm infants who have symptoms due to the ductus arteriosus may receive therapy (indomethacin) for closing that vessel. Indomethacin may decrease kidney function and the amount of urine. Furosemide, a medication which reduces body water (diuretic), might help limit the effects of indomethacin on the kidney. This review analyzed the effects of furosemide on preterm babies receiving indomethacin to close the ductus arteriosus. The review of trials found not enough evidence to recommend routine use of furosemide in preterm infants who receive indomethacin for closing a ductus arteriosus.

Continuous infusion versus bolus injection of furosemide in critically ill patients. A systematic review and meta-analysis

Bibliographic details: Zangrillo A, Cabrini L, Monti G, Stefano T, Moizo E, Vinciguerra F, Frau G, Biondi-Zoccai G G.  Continuous infusion versus bolus injection of furosemide in critically ill patients. A systematic review and meta-analysis. Signa Vitae 2011; 6(2): 58-63 Available from: http://www.signavitae.com/articles/original-articles/180

Continuous infusion versus bolus injection of furosemide in pediatric patients after cardiac surgery: a meta-analysis of randomized studies

Bibliographic details: Zangrillo A, Cabrini L, Biondi-Zoccai GG, Monti G, Turi S, Sheiban I, Bignami E, Landoni G.  Continuous infusion versus bolus injection of furosemide in pediatric patients after cardiac surgery: a meta-analysis of randomized studies. Signa Vitae 2012; 7(1): 17-22 Available from: http://www.signavitae.com/articles/original-articles/199-continuous-infusion-versus-bolus-injection-of-furosemide-in-pediatric-patients-after-cardiac-surgery-a-meta-analysis-of-randomized-studies

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Summaries for consumers

Furosemide for prevention of morbidity in indomethacin‐treated infants with patent ductus arteriosus

There is no strong evidence of benefit from routine use furosemide, a loop diuretic, in preterm babies receiving indomethacin for treatment of patent ductus arteriosus. A blood vessel (ductus arteriosus), which is required for blood circulation for the fetus in the womb, closes soon after birth in babies born around the expected date of delivery (term infants). Babies born early (preterm) may develop symptoms if they do not close that blood vessel after birth. Preterm infants who have symptoms due to the ductus arteriosus may receive therapy (indomethacin) for closing that vessel. Indomethacin may decrease kidney function and the amount of urine. Furosemide, a medication which reduces body water (diuretic), might help limit the effects of indomethacin on the kidney. This review analyzed the effects of furosemide on preterm babies receiving indomethacin to close the ductus arteriosus. The review of trials found not enough evidence to recommend routine use of furosemide in preterm infants who receive indomethacin for closing a ductus arteriosus.

Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation

Bleeding (hemorrhage) into the fluid‐producing cavities (ventricles) of the brain is a serious complication of premature birth. Large hemorrhages may result in fluid building up under pressure, progressively enlarging the brain and head. Current treatment approaches, including the insertion of a valve drainage system (shunt) are fraught with problems. Acetazolamide and furosemide, two drugs with diuretic action, reduce the production of fluid in the ventricles of the brain and have been proposed as safe treatments to treat dilatation of the ventricles after intraventricular hemorrhage in newborn infants. When compared with standard treatment, diuretic therapy was found not to reduce the need for shunt surgery. Diuretic drugs are neither safe nor effective in treating ventricular dilatation in infants with intraventricular hemorrhage.

Aerosolized diuretics for preterm infants with (or developing) chronic lung disease

There is no evidence of benefit from routine use of inhaled diuretics in preterm babies at risk of chronic lung disease. Lung disease in babies born early (preterm) is often complicated with excess accumulation of water in the lungs. Medications that reduce body water (diuretics) might help the baby recover from lung disease. In theory, giving the diuretic as an inhaled mist (aerosol) could drain water from the lung more than from the rest of the body, which could reduce adverse effects. The review found several small trials of a single type of diuretic (furosemide). A single dose improved lung function, but only temporarily. No information was available about long term outcome.

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