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Flurbiprofen

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as… Read more

Brand names include: Ansaid

Into the eye

Keeps the pupils of the eyes from getting smaller during an eye surgery. This medicine is an (NSAID)… Read more

Brand names include: Ocufen

Ophthalmic route

Flurbiprofen eye drops are used to keep the pupils of the eye from getting smaller (miosis) during an eye surgery. This medicine is a topical nonsteroidal… Read more

Brand names include: Ocufen

Drug classes About this
Analgesic, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, NSAID, Ophthalmologic Agent, Propionic Acid (class)

What works? Research summarized

Evidence reviews

Single dose oral flurbiprofen for acute postoperative pain in adults

A single dose of flurbiprofen 50 mg or 100 mg provides a high level of pain relief to 65% to 70% of those with moderate or severe postoperative pain. It has similar efficacy to other commonly used analgesics at standard doses, including ibuprofen and naproxen, with a duration of action exceeding 6 hours. Adverse events were no more common with flurbiprofen than with placebo in these single dose studies.

Efficacy and safety of flurbiprofen axetil for clincal analgesic effect: a meta-analysis

Bibliographic details: Jia H, Pei L.  Efficacy and safety of flurbiprofen axetil for clincal analgesic effect: a meta-analysis. Chinese Journal of Evidence-Based Medicine 2011; 11(12): 1409-1418 Available from: http://www.cjebm.org.cn/oa/DArticle.aspx?type=view&id=201112012

Flurbiprofen axetil for prevention of propofol injection pain in adult --- a systematic review

Bibliographic details: Sun Y, Li T, Chai F, Gan TJ.  Flurbiprofen axetil for prevention of propofol injection pain in adult --- a systematic review. Internet Journal of Anesthesiology 2011; 28: 1 Available from: http://archive.ispub.com/journal/the-internet-journal-of-anesthesiology/volume-28-number-1/flurbiprofen-axetil-for-prevention-of-propofol-injection-pain-in-adult-a-systematic-review.html

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Summaries for consumers

Single dose oral flurbiprofen for acute postoperative pain in adults

A single dose of flurbiprofen 50 mg or 100 mg provides a high level of pain relief to 65% to 70% of those with moderate or severe postoperative pain. It has similar efficacy to other commonly used analgesics at standard doses, including ibuprofen and naproxen, with a duration of action exceeding 6 hours. Adverse events were no more common with flurbiprofen than with placebo in these single dose studies.

Topical non‐steroidal anti‐inflammatory drugs (NSAIDs) for the treatment of pain in traumatic corneal abrasions

The aim of this Cochrane Review was to find out if topical (applied directly to the surface of the eye) non‐steroidal anti‐inflammatory drugs (NSAIDs) for traumatic corneal abrasions reduce pain. Cochrane researchers collected and analysed all relevant studies to answer this question. We found nine studies.

Aspirin, steroid and non‐steroidal anti‐inflammatory drugs use for treating Alzheimer's disease

Inflammation may play an important role in the development of Alzheimer’s disease. There is also some evidence from community surveys that people receiving anti‐inflammatory drugs for various medical conditions may be less likely to develop Alzheimer's disease. Fourteen studies met our inclusion criteria for this review and none of the exclusion criteria. Aspirin, steroid and non‐steroidal anti‐inflammatory drugs (NSAIDs) (traditional and the selective cyclooxygenase‐2 (COX‐2) inhibitors) showed no significant benefit in the treatment of Alzheimer's disease. Therefore, the use of these drugs cannot be recommended for the treatment of Alzheimer's disease.         

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