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Diclofenac

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild-to-moderate pain, and helps to relieve symptoms of arthritis (eg, osteoarthritis… Read more

Brand names include: Cambia, Cataflam

Into the eye

Diclofenac ophthalmic (eye) solution is used to treat pain or swelling of the eye following cataract surgery. It is also used to relieve temporary pain… Read more

Brand names include: Vofenal, Voltaren

On the skin

Treats actinic keratoses. Also treats pain and swelling caused by arthritis. This is an NSAID… Read more

Brand names include: DS Prep Pak, DST Plus Pak

On the skin

Treats pain caused by minor strains, sprains, and bruises. This medicine is an NSAID… Read more

Brand names include: Flector

Topical application route

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such… Read more

Brand names include: Flector, Klofensaid II

By injection

Diclofenac injection is a nonsteroidal anti-inflammatory drug (NSAID) used to treat adults with mild to moderate pain. It is used alone or given with… Read more

Brand names include: Dyloject

Drug classes About this
Acetic Acid (class), Analgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, NSAID, Ophthalmologic Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Diclofenac with or without an antiemetic for acute migraine headaches in adults

This review found that oral diclofenac potassium 50 mg was an effective treatment for migraine headache, reducing moderate to severe pain to no more than mild pain within two hours in about half (55%) of those treated, to no pain at two hours in about one in five (22%), and to no pain sustained to 24 hours in about the same number (19%). Adverse events were mostly self limiting and of mild or moderate intensity, and were not significantly different from placebo over the short term. Although diclofenac provided good outcomes for some people, almost half did not experience adequate pain relief within two hours, and as few as one in five became pain‐free. It is not clear whether the 100 mg dose provides good outcomes for more people. For those who do not experience adequate responses, a different therapy will be needed.

Single dose oral diclofenac for acute postoperative pain in adults

Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. Painkillers are tested in people with pain, often following a painful condition such as the removal of wisdom teeth. This pain is usually treated with painkillers taken by mouth. We believe these results can be applied to other acute painful conditions.

Diclofenac for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review

Bibliographic details: Lai W, Wang X, Deng MM, Kang DY, Jia H.  Diclofenac for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review. Chinese Journal of Evidence-Based Medicine 2012; 12(4): 470-476 Available from: http://www.cjebm.org.cn/oa/DArticle.aspx?type=view&id=201204015

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Summaries for consumers

Diclofenac with or without an antiemetic for acute migraine headaches in adults

This review found that oral diclofenac potassium 50 mg was an effective treatment for migraine headache, reducing moderate to severe pain to no more than mild pain within two hours in about half (55%) of those treated, to no pain at two hours in about one in five (22%), and to no pain sustained to 24 hours in about the same number (19%). Adverse events were mostly self limiting and of mild or moderate intensity, and were not significantly different from placebo over the short term. Although diclofenac provided good outcomes for some people, almost half did not experience adequate pain relief within two hours, and as few as one in five became pain‐free. It is not clear whether the 100 mg dose provides good outcomes for more people. For those who do not experience adequate responses, a different therapy will be needed.

Single dose oral diclofenac for acute postoperative pain in adults

Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. Painkillers are tested in people with pain, often following a painful condition such as the removal of wisdom teeth. This pain is usually treated with painkillers taken by mouth. We believe these results can be applied to other acute painful conditions.

Interventions for treating osteoarthritis in the temporomandibular joint

The temporomandibular joint (TMJ) or jaw joint is located in front of the ear on either side of the face. However, it is the only joint that the dentists and maxillofacial surgeons predominantly have to deal with. As with many of the other joints, the TMJ can be affected by osteoarthritis (OA). This is characterized by progressive destruction of the internal surfaces of the joint which can result in debilitating pain and joint noises. Several disorders other than OA may affect the TMJ and the correct diagnosis is important such that it can be matched with appropriate therapy.

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