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Chorionic Gonadotropin

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By injection

Chorionic gonadotropin is a drug whose actions are almost the same as those of luteinizing hormone (LH), which is produced by the pituitary gland. It… Read more

Brand names include: Chorex, Chorionic Gonadotropin

By injection

Used to make a woman's ovary release an egg (ovulate)… Read more

Brand names include: Ovidrel

Drug classes About this
Diagnostic Agent, Endocrine-Metabolic Agent

What works? Research summarized

Evidence reviews

Human chorionic gonadotrophin for threatened miscarriage

Threatened miscarriage is a term used when a woman who is less than 24 weeks pregnant with a live baby experiences bleeding. The mother has vaginal bleeding, with or without abdominal pain and cramps, but the cervix is closed. Miscarriage is a source of great physical and psychological distress and is very common. Causes include chromosomal abnormalities in the fetus, when the mother is older, has uterine or endocrine abnormalities or has polycystic ovarian syndrome. Human chorionic gonadotrophin (also called hCG) is a hormone produced by the placenta and is known to help maintain the pregnancy. Hence there has been much interest in the use of hCG for treating threatened miscarriage with the aim of preserving the pregnancy.This review of three trials (including 312 participants), one of which was of poor quality, found no evidence that hCG can be used as effective treatment for threatened miscarriage. There was no report on adverse effects of hCG on the mother or baby. More good‐quality research is needed to study the impact of hCG on miscarriage.

Human chorionic gonadotrophin hormone for preventing recurrent miscarriage

Miscarriage is the loss of a pregnancy before 24 weeks of gestation. Recurrent miscarriage (RM) is the loss of three or more consecutive pregnancies, which can cause significant physical and psychological harm with increased depression, anxiety and lowered self‐esteem. RM can be linked to systemic maternal disease, such as diabetes mellitus, thyroid disease and polycystic ovary syndrome. In many cases, the cause of RM may remain unknown despite thorough investigations. Current strategies for preventing RM include the administration of hormones involved in maintaining pregnancy, one of which is human chorionic gonadotrophin (hCG). This hormone is important for the continued production of progesterone from the corpus luteum and may have a role in the implantation of the embryo.

Human chorionic gonadotrophin (hCG) priming in in vitro maturation (IVM)

Cochrane authors reviewed the evidence about hCG priming in IVM to determine its effectiveness and safety in subfertile women undergoing assisted reproduction. The main outcomes were live birth and miscarriage rate.

See all (79)

Summaries for consumers

Human chorionic gonadotrophin for threatened miscarriage

Threatened miscarriage is a term used when a woman who is less than 24 weeks pregnant with a live baby experiences bleeding. The mother has vaginal bleeding, with or without abdominal pain and cramps, but the cervix is closed. Miscarriage is a source of great physical and psychological distress and is very common. Causes include chromosomal abnormalities in the fetus, when the mother is older, has uterine or endocrine abnormalities or has polycystic ovarian syndrome. Human chorionic gonadotrophin (also called hCG) is a hormone produced by the placenta and is known to help maintain the pregnancy. Hence there has been much interest in the use of hCG for treating threatened miscarriage with the aim of preserving the pregnancy.This review of three trials (including 312 participants), one of which was of poor quality, found no evidence that hCG can be used as effective treatment for threatened miscarriage. There was no report on adverse effects of hCG on the mother or baby. More good‐quality research is needed to study the impact of hCG on miscarriage.

Human chorionic gonadotrophin hormone for preventing recurrent miscarriage

Miscarriage is the loss of a pregnancy before 24 weeks of gestation. Recurrent miscarriage (RM) is the loss of three or more consecutive pregnancies, which can cause significant physical and psychological harm with increased depression, anxiety and lowered self‐esteem. RM can be linked to systemic maternal disease, such as diabetes mellitus, thyroid disease and polycystic ovary syndrome. In many cases, the cause of RM may remain unknown despite thorough investigations. Current strategies for preventing RM include the administration of hormones involved in maintaining pregnancy, one of which is human chorionic gonadotrophin (hCG). This hormone is important for the continued production of progesterone from the corpus luteum and may have a role in the implantation of the embryo.

Human chorionic gonadotrophin (hCG) priming in in vitro maturation (IVM)

Cochrane authors reviewed the evidence about hCG priming in IVM to determine its effectiveness and safety in subfertile women undergoing assisted reproduction. The main outcomes were live birth and miscarriage rate.

See all (37)

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