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Carmustine

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Implant

Carmustine implant is used together with surgery and radiation therapy to treat malignant glioma and glioblastoma multiforme. These are types of brain… Read more

Brand names include: Gliadel

By injection

Carmustine injection is used alone or together with other medicines to treat certain type of brain tumors (eg, glioblastoma, brainstem glioma, medulloblastoma,… Read more

Brand names include: Bicnu

Drug classes About this
Antineoplastic Agent

What works? Research summarized

Evidence reviews

The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation

High-grade (grade III and IV) gliomas are rare but very aggressive brain tumours. There are about 1700 new cases of high-grade glioma diagnosed annually in England (3.6/100,000). Incidence is highest among those in their early 70s and gliomas are slightly more common in men than women. High-grade gliomas are incurable and treatment aims to increase survival while maintaining quality of life. Median survival is around 1 year for those with grade IV tumours and 2–3 years for those with grade III tumours.

Treatment of high grade glioma with anti‐cancer drug (chemotherapy) coated implants

High grade glioma is a rapidly progressive form of brain tumour. Standard therapy involves the use of surgery (either biopsy or resection) and radiotherapy plus or minus temozolomide. Chemotherapy was not previously used due to concerns over efficacy and high risks of side effects.

The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation

This review found that adjuvant carmustine wafers conferred no survival advantage in patients with Grade III or IV tumours. With temozolomide there was limited evidence of a small but significant advantage in patients with Grade IV and III tumours in overall survival and progression free survival. The authors' conclusions seem appropriate given the strength of the evidence presented.

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Summaries for consumers

Treatment of high grade glioma with anti‐cancer drug (chemotherapy) coated implants

High grade glioma is a rapidly progressive form of brain tumour. Standard therapy involves the use of surgery (either biopsy or resection) and radiotherapy plus or minus temozolomide. Chemotherapy was not previously used due to concerns over efficacy and high risks of side effects.

Late Effects of Treatment for Childhood Cancer (PDQ®): Patient Version

Expert-reviewed information summary about the health problems that continue or appear after cancer treatment has ended.

PubMed Health Blog...

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