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Henderson JT, Whitlock EP, O'Conner E, et al. Low-Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Apr. (Evidence Syntheses, No. 112.)

Appendix BOngoing or Recently Completed Studies

Study, Year initiatedDesignAimLocationNumber of participantsIntervention descriptionRelevant outcomes2013 status
Odibo, 2012RCTDetermine the efficacy of low-dose aspirin for preventing preeclampsia in women identified as high risk by a first trimester multiparameter predictive modelUnited StatesEstimated enrollment: 220Aspirin (81 mg per day) until 37 weeks of gestation or labor, whichever comes firstPreeclampsiaEstimated completion: September 2014
Nicolaides, 2011RCTTo examine if the prophylactic use of low-dose aspirin from the first-trimester of pregnancy in women at increased risk for preeclampsia can reduce the incidence and severity of the diseaseUnited KingdomEstimated enrollment: 1,560Aspirin (75 mg per day) from 12 to 34 weeks of gestation or labor, whichever comes firstPreeclampsia, harmsEstimated completion: September 2016
Perrotin, 2012RCTDetermine the efficacy of low-dose aspirin, given at bedtime and started early during pregnancy, in nulliparous pregnant women selected as high-risk by the presence of a bilateral uterine artery notch or bilateral uterine artery PI ≥1.7 during the first trimester ultrasound scan, to prevent the occurrence of preeclampsiaFranceEstimated enrollment: 4,972Aspirin (160 mg per day) until 34 weeks of gestationPreeclampsiaEstimated completion: June 2015
Varea, 2012RCTDetermine whether low-dose aspirin improves trophoblastic invasion evaluated at third trimester in women defined as high-risk by abnormal uterine artery Doppler at first trimesterSpainEstimated enrollment: 270Aspirin (150 mg per day)Uterine artery mean pulsatility; preeclampsiaEstimated completion: December 2013
Cover of Low-Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia
Low-Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].
Evidence Syntheses, No. 112.
Henderson JT, Whitlock EP, O'Conner E, et al.

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