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Saxagliptin (Onglyza): Indicated in Patients with Type 2 Diabetes Mellitus to Improve Glycemic Control in Combination with Metformin and a Sulfonylurea when Dual Therapy with these Two Agents, with Diet and Exercise, does not Provide Adequate Glycemic Control [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2013 Nov.

APPENDIX 2LITERATURE SEARCH STRATEGY

OVERVIEW
Interface:Ovid
Databases:Embase 1974 to present
MEDLINE Daily and MEDLINE 1946 to present
MEDLINE In-Process & Other Non-Indexed Citations
Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:June 25, 2013
Alerts:Weekly search updates until October 16, 2013
Study Types:No search filters were applied
Limits:Date limit: 2012 to present
No language limits were used.
Conference abstracts were excluded.
SYNTAX GUIDE
/At the end of a phrase, searches the phrase as a subject heading
.shAt the end of a phrase, searches the phrase as a subject heading
*Before a word, indicates that the marked subject heading is a primary topic;
or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
adjRequires words that are adjacent to each other (in any order)
.tiTitle
.abAbstract
.hwHeading Word; usually includes subject headings and controlled vocabulary
.nmName of Substance Word
.otOriginal title
.ptPublication type
.rnCAS registry number
pmezOvid database code; MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Daily and Ovid MEDLINE 1946 to Present
oemezdOvid database code; Embase 1974 to present, updated daily
MULTI-DATABASE STRATEGY
1(onglyza* or saxagliptin* or bms477118 or (bms adj "477118")).ti,ot,ab,sh,rn,hw,nm.
2945667-22-1.rn,nm.
31 or 2
43 use pmez
5*saxagliptin/
6(onglyza* or saxagliptin* or bms477118 or (bms adj "477118")).ti,ab.
75 or 6
87 not conference abstract.pt.
98 use oemezd
104 or 9
11remove duplicates from 10
12limit 11 to yr="2012 -Current"
OTHER DATABASES
PubMedSame MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.
Trial registries
(Clinicaltrials​.gov and other)
Same keywords, limits used as per MEDLINE search.

Grey Literature

Dates of Search:July 17, 2013
Keywords:saxagliptin (Onglyza), Diabetes mellitus, type 2
Limits:Date: January 2012 to present, no language limits used

Relevant websites from the following sections of the CADTH grey literature checklist, “Grey matters: a practical tool for evidence-based searching” (http://www.cadth.ca/en/resources/finding-evidence-is/grey-matters) were searched:

  • Health Technology Assessment Agencies
  • Health Economics
  • Drug and Device Regulatory Approvals
  • Advisories and Warnings
  • Databases (free).
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Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Cover of Saxagliptin (Onglyza)
Saxagliptin (Onglyza): Indicated in Patients with Type 2 Diabetes Mellitus to Improve Glycemic Control in Combination with Metformin and a Sulfonylurea when Dual Therapy with these Two Agents, with Diet and Exercise, does not Provide Adequate Glycemic Control [Internet].

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