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RESULTS

A total of 196 studies were identified from the literature for inclusion in the systematic review (Figure 1). The included studies are summarized in Table 5 and described in Section 3.2. A list of excluded studies is presented in APPENDIX 3: EXCLUDED STUDIES.

INTRODUCTION

Uterine fibroids (UFs), leiomyomas, or myomas are benign tumours characterized by excessive or irregular uterine bleeding, which may lead to the development of anemia, pelvic pressure or pain, increased urinary frequency or constipation, and possibly compromised fertility. UFs represent one of the most common reasons for women to seek gynecological care. Nonetheless, many women with UFs are asymptomatic, such that diagnosed UFs are thought to represent only half of all cases.,

EXECUTIVE SUMMARY

Uterine fibroids, leiomyomas, or myomas are benign tumours characterized by excessive or irregular uterine bleeding (with or without anemia), pelvic pressure, or pain, which may compromise fertility; however, many women may be asymptomatic. Uterine fibroids, the risk for which rises with age until menopause, represents one of the most common reasons for women to seek gynecological care and is the leading indication for hysterectomy. Uterine fibroids are reported to affect about 35 million reproductive-aged women in the US, with a global prevalence ranging between 20% and 77%.

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