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Vancomycin or Metronidazole for Treatment of Clostridium difficile Infection: Clinical and Economic Analyses [Internet]

Vancomycin or Metronidazole for Treatment of Clostridium difficile Infection: Clinical and Economic Analyses [Internet]

CADTH Technology Report - Canadian Agency for Drugs and Technologies in Health

Version: January 2011

BACKGROUND

Clostridium difficile (C. difficile) is an anerobic, gram-positive, spore-forming bacillus. The transmission of C. difficile occurs through spores or bacteria in stools or through spores in the environment. Environmental spores are resistant to many disinfectants. They can survive for months or years. Healthy individuals who are colonized with C. difficile may be asymptomatic carriers, or they may develop symptoms. Among healthy adults in the community, the colonization rates of C. difficile range from 2.4% to 13.0%. Between 40% to 60% of neonates are asymptomatic carriers.

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