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Fortin P, Mintzes B, Innes M. A Systematic Review of Intravitreal Bevacizumab for the Treatment of Diabetic Macular Edema [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2012 May.


Databases:EMBASE 1980-
Ovid MEDLINE In-Process & Other Non-Indexed Citations 1948-
Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:November 16, 2011
April 2, 2012 (Updated)
AlertsWeekly search alerts began April 2, 2012 and ran until May 1, 2012
Study Types:No filters were applied to limit the retrieval by study type
Limits:Original search: Human
      No date or language limits
Update search: Publication years October 21, 2011-April 2, 2012
      English language
      Conference abstracts removed
/At the end of a phrase, searches the phrase as a subject heading
.shAt the end of a phrase, searches the phrase as a subject heading
MeSHMedical Subject Heading
use pmezRestrict to MEDLINE database
use emefRestrict to EMBASE database
*Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
#Truncation symbol for one character
?Truncation symbol for one or no characters only
ADJRequires words are adjacent to each other (in any order)
ADJ#Adjacency within # number of words (in any order)
.hwHeading Word; usually includes subject headings and controlled vocabulary
.ptPublication type
.rnCAS registry number
Multi-database Strategy
Original search:
2diabetic retinopathy/ (
3(diabet$ adj2 retinopath$).tw.
4macular edema/
5((central or diabetes or diabetic or fovea or macula or macular or retina or retinal) adj2 (edema? or oedema?)).tw.
7(irvine-gass adj2 syndrome).tw.
9(avastin or bevacizumab).mp.
10randomized controlled
11controlled clinical
14drug therapy.fs.
19animals/ not (humans/ and animals/)
2018 not 19
211 and 8 and 9 and 20
Update search:
1(avastin* or bevacizumab*).ti,ab,hw. use pmez
2*bevacizumab/ or (avastin* or bevacizumab*).ti,ab. use emef
31 or 2
4exp retinal diseases/ use pmez
5exp retina macula edema/ use emef
6(eye* or retin* or intraocular* or intravitreal* or panretin* or ophthalm* or ocular or vision or visual or macular).ti,ab. or diabet*.ti,ab,hw.
74 or 5 or 6
83 and 7
9limit 8 to english language
10limit 9 to yr="2011 -Current"
11remove duplicates from 10
1311 not 12
14.exp animals/
15.exp animal experimentation/
16.exp models animal/
17.exp animal experiment/
19.exp vertebrate/
22.exp humans/
23.exp human experiment/
26.21 not 25
26.13 not 26
PubMed (update search only)Same MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.
The CochraneSame MeSH, keywords, and date limits used as per MEDLINE search.
(2011 and 2012 issue 3)
Syntax adjusted for Cochrane Library databases.

Grey Literature

Dates forOriginal search: No date limit
Search:Update search: 2011 — April 2, 2012
Keywords:Avastin or bevacizumab and included terms for ocular conditions
Limits:Same as database limits (see above)

The following sections of the CADTH grey literature checklist, “Grey matters: a practical tool for evidence-based medicine” ( were searched:

  • Health Technology Assessment Agencies
  • Databases (free)
  • Advisories and Warnings
  • Internet Search.
Copyright © CADTH (May 2012)

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at

Cover of A Systematic Review of Intravitreal Bevacizumab for the Treatment of Diabetic Macular Edema
A Systematic Review of Intravitreal Bevacizumab for the Treatment of Diabetic Macular Edema [Internet].
Fortin P, Mintzes B, Innes M.

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