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Comparative Clinical and Cost-Effectiveness of Drug Therapies for Relapsing-Remitting Multiple Sclerosis [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2013 Oct. (CADTH Therapeutic Review, No. 1.2B.)

APPENDIX 4COST TABLE

Table 44Cost Table of RRMS Treatments

Drug/ComparatorStrengthDosage
Form
Unit Cost
($)
Recommended
Treatment
Regimen
Annual Drug
Cost ($)
Alemtuzumab12 mg

24 mg
VialN/A12 mg for 5 consecutive days at first month, 3 consecutive days at month 12

24 mg for 5 consecutive days at first month, 3 consecutive days at month 12
$40,281a
Dimethyl fumarate (Tecfidera)240 mgCapN/A240 mg twice daily$23, 019b
Fingolimod (Gilenya)0.5 mgCap85.1648once daily$31,170
Glatiramer acetate (Copaxone)20 mg/mLPre-filled syringe44.496020 mg daily$16,286
Interferon beta-1a (Avonex)30 mcg/0.5 mLPre-filled syringe393.940030 mcg IM per week$20,597
Interferon beta-1a (Rebif)22 mcg (6 MIU)Pre-filled syringe128.843322 mcg given 3 times per week$20,210
Interferon beta-1a (Rebif)44 mcg (12 MIU)Pre-filled syringe156.853344 mcg given 3 times per week$24,604
Interferon beta-1b (Betaseron)0.3 mgInjection110.0000250 mcg SC every other day$20,130
Interferon beta-1b (Extavia)0.3 mgPowder for injection99.3593250 mcg SC every other day$18,183
Natalizumab (Tysabri)300 mg/15 mLVial3081.5800300 mg IV infusion every four weeks$40,281
Teriflunomide7 mg
14 mg
TabN/A7 mg oral daily
14 mg oral daily
$24,184c

Source: Ontario Exceptional Access Program (EAP) (June 2013)

IM = intramuscular; IV = intravenous; mcg = microgram; mg = milligram; N/A = not available; SC = subcutaneous.

a

The price of alemtuzumab is unavailable, and it was assumed to be the same as for natalizumab.

b

The price of dimethyl fumarate was provided by the manufacturer.

c

The assumed price of teriflunomide was based on the ratio between the price of fingolimod and the price of teriflunomide in the US.73

Copyright © CADTH March 2013.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Cover of Comparative Clinical and Cost-Effectiveness of Drug Therapies for Relapsing-Remitting Multiple Sclerosis
Comparative Clinical and Cost-Effectiveness of Drug Therapies for Relapsing-Remitting Multiple Sclerosis [Internet].
CADTH Therapeutic Review, No. 1.2B.

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