Table 30Utility Values

Variable DescriptionBase EstimateProbability Distribution*Reference
Long-term utilities:
  Atrial fibrillation
  Previous major stroke
    Rankin score 3 to 4
    Rankin score 5
    Probability major stroke is 5
  Previous minor stroke
  Previous ICH
  Previous MI (decrement)
  Decrement per year over 70 years

0.810
0.333
0.390
0.110
0.205
0.75
0.75
0.012
0.00029

Beta (33.82, 7.93)
N/A
Beta (69.74, 109.08)
Beta (18.93, 153.16)
Beta (8, 39)
Beta (86.69, 28.90)
Beta (86.69, 28.90)
Normal (0.012, 0.0002)
Normal (0.00029,0.00002)

Sullivan (2006)93

Gage (1996)94
Gage (1996)94
FDA (2010)79
Gage (1996)94
Gage (1996)94
Sullivan (2005)95
Sullivan (2006)93
Decrements associated with events:
  MI
  Major bleeds
  Minor bleeds
  PE
  TIA

0.125
0.092
0.013
0.022
0.103

Normal (−0.125, 0.009)
Normal (−0.092, 0.010)
Normal (−0.013, 0.001)
Normal (−0.022, 0.003)
Normal (−0.103, 0.008)

Sullivan (2006)93
Freeman (2011)57
Freeman (2011)57
Gould (1999)96
Sullivan (2006)93
*

Beta distributions parameterized by alpha and beta, normal distributions parameterized by means and standard errors.

Derived from; utility decrements calibrated to apply for one month.

From: 4, ECONOMIC REVIEW

Cover of Safety, Effectiveness, and Cost-Effectiveness of New Oral Anticoagulants Compared with Warfarin in Preventing Stroke and Other Cardiovascular Events in Patients with Atrial Fibrillation
Safety, Effectiveness, and Cost-Effectiveness of New Oral Anticoagulants Compared with Warfarin in Preventing Stroke and Other Cardiovascular Events in Patients with Atrial Fibrillation [Internet].
Wells G, Coyle D, Cameron C, et al.
Copyright © 2012 Canadian Collaborative for Drug Safety, Effectiveness and Network Meta-Analysis.

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