Table 32Vitamin D Evidence Summary

Study QualityStudy design Followup (max)Supplement and dose Supplement durationNMean age (y)% FemaleCVD incidenceCancer incidenceMortalityHarmsComments
RECORD103,106,107

Fair
2×2 factorial RCT

6.2 years
Vitamin D3 800 IU qd (alone or in combination with calcium 1,000 mg qd)

3.75 years (median) (range, 2 to 5.2 years)
5,2927785Any: ↔
MI: ↔
Stroke: ↔
Any: ↔
Lung: ↔
CRC: ↔
Prostate: ↔
Breast: ↔
Other: ↔
Trivedi 2003104

Fair
RCT
5 years
Vitamin D3 100,000 IU every 4 months

5 years
2,6867524Any: ↔ MI: NR Stroke: ↔Any: ↔
Lung: ↔
CRC: ↔
Prostate: NR
Breast: NR
Other: NR
NR
Dean, 2011105

Good
RCT

0.1 years
Vitamin D 5,000 IU qd

0.1 years
1282257NANANA
*

CVD mortality only.

Cancer and CVD-related mortality also reported; no significant difference between groups.

Abbreviations: bid = twice daily; CRC = colorectal cancer; CVD = cardiovascular disease; max = maximum; MI = myocardial infarction; NA = not applicable; NR = not reported; qd = once daily; RCT = randomized, controlled trial; RECORD = Randomized Evaluation of Calcium or Vitamin D; y = years.

Legend: ↑ (statistically significant increase in risk of outcome from supplementation), ↔ (no statistically significant difference between intervention groups), ↓ (statistically significant decrease in risk of outcome from supplementation).

From: 3, Results

Cover of Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer
Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].
Evidence Syntheses, No. 108.
Fortmann SP, Burda BU, Senger CA, et al.

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