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Antithrombotic Agents for the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2013 Mar. (CADTH Therapeutic Review, No. 1.1B.)

APPENDIX 16COMPARISON OF MODEL FIT STATISTICS: FIXED-EFFECTS VS RANDOM-EFFECTS MODELS

OutcomeFixed-effects ModelRandom-effects Model
All-cause Stroke or
Systemic Embolism*
DIC = 146.15
Deviance vs. unconstrained data points: 19.28 vs 19
DIC = 147.07
Deviance vs. unconstrained data points: 18.83 vs 19
Major BleedingDIC = 141.66
Deviance vs. unconstrained data points: 22.15 vs. 22
DIC = 142.14
Deviance vs. unconstrained data points: 21.59 vs.22
All-cause MortalityDIC = 158.64
Deviance vs. unconstrained data points: 19.13 vs. 21
DIC = 160.40
Deviance vs. unconstrained data points: 19.72 vs. 21
Extracranial hemorrhageDIC = 129.13
Deviance vs. unconstrained data points: 20.34 vs. 19
DIC = 128.88
Deviance vs. unconstrained data points: 19.81 vs. 19
Intracranial hemorrhageDIC = 102.90
Deviance vs. unconstrained data points: 16.11 vs. 17
DIC = 103.15
Deviance vs. unconstrained data points: 16.21 vs. 17
Myocardial InfarctionDIC = 96.40
Deviance vs. unconstrained data points: 13.11 vs. 13
DIC = 96.45
Deviance vs. unconstrained data points: 13.13 vs. 13
*

Small differences in fit between fixed and random-effects model driven by Deviance in warfarin arm of AFASAK study.

Small differences in fit between fixed and random-effects model driven by Deviance in both arms of WASPO study.

Small differences in fit between fixed and random-effects model driven by Deviance in both arms of JAST study.

DIC = Deviance information criterion (a measure of model fit that penalizes model complexity). The lower the number the better the fit.

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Cover of Antithrombotic Agents for the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation
Antithrombotic Agents for the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation [Internet].
CADTH Therapeutic Review, No. 1.1B.

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