NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Yan JY, Nie XL, Tao QM, Zhan SY, Zhang YD. Ketoconazole associated hepatotoxicity: a systematic review and meta-analysis. Biomedical and Environmental Sciences 2013; 26(7): 605-610. [PubMed: 23895707]
Abstract
OBJECTIVE: To evaluate the incidence of Ketoconazole associated hepatotoxicity and related factor.
METHODS: Literature retrieval was conducted by using multi-databases for meta-analysis on Ketoconazole associated hepatotoxicity. The data were collected with a standardized form. Overall estimation of incidence of hepatotoxicity for specific study type was calculated by using a DerSimonian-Laird random-effects model owing to the substantial differences among the studies.
RESULTS: Totally 204 eligible studies were included in the analysis. The incidence of Ketoconazole associated hepatotoxicity was 3.6%-4.2%. The dosage and duration specific subgroup analyses did not show any significant difference among groups, while the age specific subgroup analysis showed the incidence in children and people aged >60 years was 1.4% (95% CI: 0.5%-4.2%) and 3.2% (95% CI: 1.1%-8.7%) respectively. Additionally, the incidence of the hepatotoxicity was higher in people who had oral administration of ketoconazole beyond the provisions of the usage instructions, and the incidence was 5.7% (95% CI: 4.5%-7.2%).
CONCLUSION: Ketoconazole associated hepatotoxicity was common. Off-label use might increase the risk of liver damage. Well-designed large sample studies are needed to identify the risk factors in future.
Copyright © 2013 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.
- Review Drug safety assessment of oral formulations of ketoconazole.[Expert Opin Drug Saf. 2015]Review Drug safety assessment of oral formulations of ketoconazole.Gupta AK, Daigle D, Foley KA. Expert Opin Drug Saf. 2015 Feb; 14(2):325-34. Epub 2014 Nov 20.
- Review The Rise and Fall of Oral Ketoconazole.[J Cutan Med Surg. 2015]Review The Rise and Fall of Oral Ketoconazole.Gupta AK, Lyons DC. J Cutan Med Surg. 2015 Jul-Aug; 19(4):352-7. Epub 2015 Mar 5.
- Ketoconazole-induced hepatotoxicity.[Hepatology. 1997]Ketoconazole-induced hepatotoxicity.Bernuau J, Durand F, Pessayre D. Hepatology. 1997 Sep; 26(3):802.
- Review Liver injury associated with ketoconazole: review of the published evidence.[J Clin Pharmacol. 2014]Review Liver injury associated with ketoconazole: review of the published evidence.Greenblatt HK, Greenblatt DJ. J Clin Pharmacol. 2014 Dec; 54(12):1321-9. Epub 2014 Oct 1.
- Oral Azole Antifungal Medications and Risk of Acute Liver Injury, Overall and by Chronic Liver Disease Status.[Am J Med. 2016]Oral Azole Antifungal Medications and Risk of Acute Liver Injury, Overall and by Chronic Liver Disease Status.Lo Re V 3rd, Carbonari DM, Lewis JD, Forde KA, Goldberg DS, Reddy KR, Haynes K, Roy JA, Sha D, Marks AR, et al. Am J Med. 2016 Mar; 129(3):283-91.e5. Epub 2015 Nov 17.
- Ketoconazole associated hepatotoxicity: a systematic review and meta-analysis - ...Ketoconazole associated hepatotoxicity: a systematic review and meta-analysis - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
Your browsing activity is empty.
Activity recording is turned off.
See more...