Table 19KQ1 – Memory-Related Disorders: Outcomes Reported in Trials of Therapy with Family Component versus Usual Care or Wait List Control

Author, yearN#Study quality+Physical functioningCognitive functionQuality of life/overall functioningSymptom management/controlDepression/anxietyUtilizationRelationship adjustment
MEMORY: Family assisted approaches, including skill training, to improve patient outcomes (n=7)
Burgener 199865++54poor±±
Gitlin 200157202poor↔/↑↔/↑
Gitlin 20087460good↔/
Martin Cook 20056047poor
Quayhagen 200062++103poor
Teri 20056695fair↔/↑↔/↑
Wright 20016793poor±
MEMORY: Family focused CBT interventions: skill building, family coping and problem solving to address patient behaviors and family issues (n=6)
Brodaty 20095952poor
Gitlin 201075272fair±/↑
Mittelman 2004,54 200652406good±↔/↑
Ostwald 199950117good
Teri 199770++72fair↔/↑/↔
Wray 201049158fair
MEMORY: Unique intervention (n=6)
Bass 200356182fair
Camberg 199911++54fair
Logsdon 201063142poor
McCallion 19996866fair↔/↑/↔
Robison 200753388poor
Teri 200312153fair↔/↑

RATINGS: ↑ Tx significantly better than comparator; ↔ No significant difference between intervention and comparator; ↓ Treatment significantly worse than comparator; ± Significance not reported or could not be determined

#

Number randomized

+

Good (low risk of bias): The trial reported adequate allocation concealment, a minimum of single blinding (participants or investigators or assessors are blinded), and that either intent-to-treat analysis was conducted or clear reasons for dropouts/attrition by group were provided. Fair (moderate risk of bias): The trial met or was unclear for allocation concealment and blinding with no more than one of the remaining domains (ITT, withdrawals) unmet. A trial with adequate allocation concealment that did not meet other domains was rated fair. Poor (high risk of bias): The trial had inadequate allocation concealment or blinding and/or clearly met only one of the established risks of bias domains.

++

Multi-arm trials that are also evaluated in KQ2.

From: RESULTS

Cover of Effectiveness of Family and Caregiver Interventions on Patient Outcomes Among Adults with Cancer or Memory-Related Disorders: A Systematic Review
Effectiveness of Family and Caregiver Interventions on Patient Outcomes Among Adults with Cancer or Memory-Related Disorders: A Systematic Review [Internet].
Griffin JM, Meis L, Greer N, et al.
Washington (DC): Department of Veterans Affairs (US); 2013 Apr.

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