Table 12Body of evidence for placement of inferior vena cava filter versus no filter in the prevention of VTE in hospitalized patients with trauma

Author, YearOutcomeRisk of BiasDirectnessPrecisionConsistencyStrength of Evidence and Magnitude of Effect
PEHighDirectPreciseConsistentLow that IVC filter placement is associated with a lower incidence of PE in hospitalized patients with trauma compared with no IVC filter placement
RR 0.20 (95% CI = 0.06 to 0.70; I2=0%)*
Rajesekhar, A 201152HighDirectImpreciseConsistent0% vs. 6.2%
Wilson JT, 199455HighDirectImprecise0% vs. 7.2%
Gosin JS, 199756HighDirectPrecise0% vs. 4.8%
Gorman PH, 200957ModerateDirectImprecise1.8% vs. 0%
Khansarinia, S 199558HighDirectPrecise0% vs. 6.0%
Rodriguez JL, 199659HighDirectPrecise2.5% vs. 17.5%
Author, YearFatal PEHighDirectPreciseConsistentLow that IVC filter placement is associated with a lower incidence of fatal PE in hospitalized patients with trauma compared with no IVC filter placement
RR 0.09 (0.01 to 0.81; I2= 0%)*
*Rajesekhar, A 201152HighDirectImpreciseConsistent0% vs. 0%
Wilson JT, 199455HighDirectImprecise0% vs. 2.7%
Khansarinia, S 199558HighDirectPrecise0% vs. 5.5%
Rodriguez JL, 199659HighDirectImprecise0% vs. 10.0%
Author, YearMortalityHighDirectImpreciseInconsistentInsufficient that IVC filter placement is associated with less mortality in hospitalized patients with trauma compared with no IVC filter placement
RR 0.70 (0.40 to 1.23; I2=6.7%)
*Rajesekhar, A 201152HighDirectImpreciseInconsistent5.5% vs. 0%
Khansarinia, S 199558HighDirectImprecise16.6% vs. 21.7%
Rodriguez JL, 199659HighDirectImprecise5.0% vs. 16.2%
Author, YearDVTHighDirectImpreciseInconsistentInsufficient that IVC filter placement is associated with a higher incidence of DVT compared with no IVC filter placement
RR 1.76 (95% CI = 0.49 to 6.18; I2= 56.8%):p=0.38
Rajesekhar, A 201152HighDirectImpreciseInconsistent5.5% vs. 0%
Rodriguez JL, 199659HighDirectImprecise15.0% vs. 18.7%
Gorman PH, 200957ModerateDirectPrecise20.4% vs. 5.2%
Author, YearFilter related thrombosis**HighDirectImpreciseUnknownInsufficient to support that IVC filter placement is associated with a higher incidence of filter related thrombosis compared with no IVC filter placement
Khansarinia, S 199558HighDirectImpreciseunknown1.8% vs. 0%

DVT = deep vein thrombosis; IVC = inferior vena cava; RCT = randomized controlled trial; RR = relative risk; VTE = venous thromboembolism

*

No VTE-related deaths in the RCT.

**

Graded on Filter related thrombosis. Data were too sparse on other complications such as filter tilt and migration to provide meaningful SOE grades on these specific complications.

From: Results

Cover of Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations
Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations [Internet].
Comparative Effectiveness Reviews, No. 116.
Singh S, Haut ER, Brotman DJ, et al.

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