Table 1Pharmacological classes for migraine prevention

Drug, ATC Code*Class of Drug
ANTIEPILEPTICS
Topiramate, N03AX11N03 ANTIEPILEPTICS N03AX Other antiepileptics
Lamotrigine, N03AX09N03A ANTIEPILEPTICS
Levetiracetam, N03AX14N03A ANTIEPILEPTICS
Pregabalin, N03AX16N03A ANTIEPILEPTICS alpha2-delta agonist
Carbamazepine, N03AF01N03A ANTIEPILEPTICS N03AF Carboxamide derivatives
Valproic acid, N03AG01N03A ANTIEPILEPTICS N03AG Fatty acid derivatives, Gamma-aminobutyric acid (GABA) enhancer and analog
Vigabatrin, N03AG04N03A ANTIEPILEPTICS N03AG Fatty acid derivatives, GABA transaminase inhibitor
Tiagabine, N03AG06N03A ANTIEPILEPTICS N03AG Fatty acid derivatives, gamma aminobutyric acid (GABA) enhancer
Zonisamide, N03AX15N03A ANTIEPILEPTICS N03AX Other antiepileptics
ValproateN03A ANTIEPILEPTICS
N03AG Fatty acid derivatives
DivalproexGamma-aminobutyric acid (GABA) enhancer and analog
Gabapentin, N03AX12N03A ANTIEPILEPTICS
Acetazolamide, S01EC01S01EC, carbonic anhydrase inhibitor
ANTIDEPRESSANTS
Nortriptyline, N06AA10N06A ANTIDEPRESSANTS N06AA nonselective monoamine reuptake inhibitors
Clomipramine, N06AA04N06A ANTIDEPRESSANTS N06AA nonselective monoamine reuptake inhibitors
Citalopram, N06AB04N06A ANTIDEPRESSANTS N06AB selective serotonin reuptake inhibitors
Venlafaxine, N06AX16N06A ANTIDEPRESSANTS N06AX Other antidepressants
AmitriptylineN06A ANTIDEPRESSANTS N06AA nonselective monoamine reuptake inhibitors
Mirtazapine, N06AX11N06A ANTIDEPRESSANTS tricyclic antidepressants
BETA BLOCKERS
Timolol, C07AA06C07AA, Beta blocking agents, nonselective
Nadolol, C07AA12C07AA Beta blocking agents, nonselective
Propranolol,C07AA05C07AA Beta blocking agents, nonselective
Metoprolol,C07AB02C07AB Beta blocking agents, selective
Atenolol, C07AB03C07AB Beta blocking agents, selective
Bisoprolol,C07AB07C07AB Beta blocking agents, selective
Acebutolol,C07AB04C07AB Beta blocking agents, selective
Alprenolol, C07AA01C07A BETA BLOCKING AGENTS
Oxprenolol, C07AA02 (discontinued in the FDA)C07AA Beta blocking agents, nonselective
Pindolol, C07AA03C07AA Beta blocking agents, nonselective
ACE INHIBITORS
Trandolapril, C09AA10C09AA ACE inhibitors
Enalapril,C09AA02C09AA ACE inhibitors
Captopril,C09AA01C09AA ACE inhibitors
Lisinopril, C09AA03C09AA ACE inhibitors
ANGIOTENSIN II ANTAGONISTS
Telmisartan,C09CA07C09CA Angiotensin II antagonists
Candesartan, C09CA06C09CA Angiotensin II antagonists
CALCIUM CHANNEL ANTAGONIST
DotarizineSELECTIVE CALCIUM CHANNEL ANTAGONIST; 5-HT receptors ANTAGONIST
Flunarizine, N07CA03; SibeliumSELECTIVE CALCIUM CHANNEL ANTAGONISTN07C ANTIVERTIGO PREPARATIONS
SELECTIVE CALCIUM CHANNEL BLOCKERS
Nimodipine,C08CA06C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS C08CA Dihydropyridine derivatives
Verapamil,C08DA01C08D SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS C08DA Phenylalkylamine derivatives
Nicardipine,C08CA04C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS C08CA Dihydropyridine derivatives
Nifedipine,C08CA05C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS C08CA Dihydropyridine derivatives
ANTIADRENERGICS
Clonidine,C02AC01C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING C02AC
Imidazoline receptor agonists
Labetalol, C07AG01C07AG, Alpha and beta blocking agents
Dixarit (clonidine, C02AC01)
Guanfacine, C02AC02
C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING C02AC Imidazoline receptor agonists
ANTI-DEMENTIA
Donepezil, N06DA02N06 PSYCHOANALEPTICS
Memantine, N06DX01N06D ANTI-DEMENTIA DRUGS N-methyl-D-aspartate (NMDA) receptor inhibitor
ANTIPSYCHOTICS
Aripiprazole,N05AX12N05A ANTIPSYCHOTICS
Olanzapine,N05AH03N05A ANTIPSYCHOTICS N05AH Diazepines, oxazepines, thiazepines and oxepines
Quetiapine,N05AH04N05A ANTIPSYCHOTICS N05AH Diazepines, oxazepines, thiazepines and oxepines
Deanxit (Flupentixol, N05AF01)N05A ANTIPSYCHOTICS
N05AF Thioxanthene derivatives
Sulpiride, N05AL01 (antipsychotic)N05A ANTIPSYCHOTICS
N05AL Benzamides
Prochlorperazine, N05AB04N05A ANTIPSYCHOTICS
DOPAMINERGIC AGENTS
Amantadine, N04BB01N04B DOPAMINERGIC AGENTS N04BB Adamantane derivatives N-methyl-D-aspartate (NMDA) receptor inhibitor
Dihydroergocryptine, N04BC03N04B DOPAMINERGIC AGENTS
N04BC Dopamine agonists
ERGOT ALKALOIDS
Dihydroergotamine, N02CA01N02C ANTIMIGRAINE PREPARATIONS N02CA Ergot alkaloids
Lisuride, N02CA07
Ergotamine, N02CA02
N02C ANTIMIGRAINE PREPARATIONS
N02C ANTIMIGRAINE PREPARATIONS N02CA Ergot alkaloids
Methysergide, N02CA04N02C ANTIMIGRAINE PREPARATIONS N02CA Ergot alkaloids
MUSCLE RELAXANTS
Botulinum Toxin Type A, M03AX01M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS M03AX Other muscle relaxants, peripherally acting agents
Tizanidine, M03BX02M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
SYSTEMIC DRUGS
Montelukast, R03DC03R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES R03DC Leukotriene receptor antagonists

ATC code - The Anatomical Therapeutic Chemical classification

From: Appendix B, Analytical Framework

Cover of Migraine in Adults: Preventive Pharmacologic Treatments
Migraine in Adults: Preventive Pharmacologic Treatments [Internet].
Comparative Effectiveness Reviews, No. 103.
Shamliyan TA, Kane RL, Taylor FR.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.