| Domains Pertaining to Strength of Evidence | Magnitude of Effect | Strength of Evidence | ||||
|---|---|---|---|---|---|---|
| Number of Studies; Number of Subjects | Risk of Bias; Design | Consistency | Directness | Precision | Summary Effect Size (95% CI) | High, Moderate, Low, Insufficient |
| Withdrawals due to Adverse Events | ||||||
| 3; 766 | Medium; RCTs | Consistent (I2=4.3%) | Direct | Imprecise | RD −0.01 (−0.04 to 0.03) | Low |
| Headaches | ||||||
| 3; 776 | Medium; RCTs | Consistent (I2=28.2%) | Direct | Imprecise | RD 0.03 (−0.04 to 0.09) | Insufficient |
| Nausea | ||||||
| 2; 712 | Medium; RCTs | Consistent (I2=0%) | Direct | Imprecise | RD 0.05 (0.00 to 0.09) | Low |
| Insomnia | ||||||
| 1; 301 | Medium; RCT | NA, single study | Direct | Imprecise | RD 0.03 (−0.06 to 0.11) | Insufficient |
| Dry mouth | ||||||
| 0; 0 | NA | NA | NA | NA | NA | Insufficient |
| Diarrhea | ||||||
| 1; 64 | Medium; RCT | NA, single study | Direct | Imprecise | RD 0.24 (0.01 to 0.47) | Insufficient |
| Dizziness | ||||||
| 0; 0 | NA | NA | NA | NA | NA | Insufficient |
| Fatigue | ||||||
| 0; 0 | NA | NA | NA | NA | NA | Insufficient |
| Somnolence | ||||||
| 1; 411 | Medium; RCT | NA, single study | Direct | Imprecise | RD 0.05 (0.00 to 0.10) | Insufficient |
| Drowsiness | ||||||
| 0; 0 | NA | NA | NA | NA | NA | Insufficient |
| Decreased appetite | ||||||
| 0; 0 | NA | NA | NA | NA | NA | Insufficient |
| Increased appetite | ||||||
| 0; 0 | NA | NA | NA | NA | NA | Insufficient |
| Constipation | ||||||
| 0; 0 | NA | NA | NA | NA | NA | Insufficient |
Abbreviations: CI = confidence interval; NA = not applicable; RCT = randomized controlled trial
From: Appendix G, Strength of Evidence
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