Figure F-103 is titled “PTSD symptom reduction (any measure) for SSRIs compared with placebo: Sensitivity analysis including studies with high risk of bias.” The figure displays a forest plot reporting standardized mean difference in PTSD symptoms stratified by citalopram versus placebo, fluoxetine versus placebo, paroxetine versus placebo, and sertraline versus placebo. The plot depicts greater reductions in PTSD symptom scores for patients treated with placebo than citalopram (1 trial, standardized mean difference 0.34, 95% CI −0.40 to 1.08). On the other hand, the plot also depicts greater reductions in PTSD symptom scores for patients treated with fluoxetine (7 trials, standardized mean difference −0.3, 95% CI −0.44 to −0.17, I2=0.0%), paroxetine (4 trials, standardized mean difference −0.47, 95% CI −0.59 to −0.35, I2=0.0%), or sertraline (8 trials, standardized mean difference −0.25, 95% CI −0.42 to −0.07, I2=46.3%) than placebo. The overall analysis continued to favor SSRIs (standardized mean difference −0.32, 95% CI −0.42 to −0.22, I2=41.8%).

Figure F-103PTSD symptom reduction (any measure) for SSRIs compared with placebo: Sensitivity analysis including studies with high risk of bias

Note: Hertzberg et al., 2000, and Marshall et al., 2007, were rated as having a high risk of bias.

Timing of outcome assessment: 10 weeks (Tucker, 2003; Marshall, 2007; Panahi, 2011; Tucker, 2004; Zohar, 2002), 12 weeks (Connor, 1999; Hertzberg, 2000; Martenyi, 2007; Marshall, 2001; Tucker, 2001; Brady, 2005; Brady, 2000; Davidson, 2001; Friedman, 2007), 8 weeks (van der Kolk, 2007), 5 weeks (van der Kolk, 1994), 24 weeks (Davidson, 2006).

From: Appendix F, Meta-Analysis

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD)
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD) [Internet].
Comparative Effectiveness Reviews, No. 92.
Jonas DE, Cusack K, Forneris CA, et al.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.