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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Harman G, Akbari A, Hiremath S, White CA, Ramsay T, Kokolo MB, Craig J, Knoll GA. Accuracy of cystatin C-based estimates of glomerular filtration rate in kidney transplant recipients: a systematic review. Nephrology Dialysis Transplantation 2013; 28(3): 741-757. [PubMed: 23275574]
Abstract
BACKGROUND: As with creatinine, cystatin C can be incorporated into a formula to estimate the glomerular filtration rate (GFR). The overall performance of cystatin C-based equations in kidney transplantation is unclear with conflicting results between studies.
METHODS: Systematic review of adult kidney transplant recipients. Studies that reported mean bias (mean difference between the measured and estimated GFRs) or accuracy of the cystatin C-based GFR estimation equation (e.g. percentage of estimates within 30% of the measured GFR) against the measured GFR using renal or plasma clearance of contrast agents, radioisotopes or inulin were included.
RESULTS: The search identified 10 studies that examined 14 different cystatin C-based estimating equations (n = 5 equations evaluated in more than one study). The Le Bricon equation had the best performance with a bias that ranged from -6.4 to +2.8 mL/min/1.73 m(2); 85% (95% CI, 82-88) of estimates were within 30% of the measured GFR. For the other equations, 66-82% of estimates were within 30% of the measured GFR. For the modification of diet in renal disease (MDRD) equation, 68% (95% CI, 65-72) of estimates were within 30% of the measured GFR.
CONCLUSIONS: The cystatin C-based Le Bricon equation was the most accurate, and most of the cystatin C-based equations showed improvements in 30% and 50% accuracy compared with the creatinine-based MDRD equation. Cystatin C-based equations may offer an advantage over the MDRD equation in kidney transplant recipients. Estimating equations re-expressed with standardized cystatin C have been developed and their accuracy needs to be tested in the kidney transplant population.
- Estimation of glomerular filtration rate with creatinine-based versus cystatin C-based equations in kidney transplant recipients.[Iran J Kidney Dis. 2009]Estimation of glomerular filtration rate with creatinine-based versus cystatin C-based equations in kidney transplant recipients.Savaj S, Shoushtarizadeh T, Abbasi MA, Razavimanesh SH, Ghods AJ. Iran J Kidney Dis. 2009 Oct; 3(4):234-8.
- Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods.[J Am Soc Nephrol. 2005]Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods.White C, Akbari A, Hussain N, Dinh L, Filler G, Lepage N, Knoll GA. J Am Soc Nephrol. 2005 Dec; 16(12):3763-70. Epub 2005 Oct 19.
- Diagnostic accuracy of various glomerular filtration rates estimating equations in patients with chronic kidney disease and diabetes.[Chin Med J (Engl). 2010]Diagnostic accuracy of various glomerular filtration rates estimating equations in patients with chronic kidney disease and diabetes.Li HX, Xu GB, Wang XJ, Zhang XC, Yang JM. Chin Med J (Engl). 2010 Mar 20; 123(6):745-51.
- Review Performance of creatinine-based estimates of GFR in kidney transplant recipients: a systematic review.[Am J Kidney Dis. 2008]Review Performance of creatinine-based estimates of GFR in kidney transplant recipients: a systematic review.White CA, Huang D, Akbari A, Garland J, Knoll GA. Am J Kidney Dis. 2008 Jun; 51(6):1005-15. Epub 2008 May 2.
- Review A Comparison of GFR estimating formulae based upon s-cystatin C and s-creatinine and a combination of the two.[Nephrol Dial Transplant. 2008]Review A Comparison of GFR estimating formulae based upon s-cystatin C and s-creatinine and a combination of the two.Tidman M, Sjöström P, Jones I. Nephrol Dial Transplant. 2008 Jan; 23(1):154-60. Epub 2007 Oct 2.
- Accuracy of cystatin C-based estimates of glomerular filtration rate in kidney t...Accuracy of cystatin C-based estimates of glomerular filtration rate in kidney transplant recipients: a systematic review - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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