Table 45Botulinum toxin type A (Dysport) versus placebo Maximum cystometric capacity - Clinical study characteristics and clinical summary of findings

No. of studiesDesignTreatment (n)Control (n)ResultsLimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
Maximum cystometric capacity
1 [A]RCTBotulinum toxin type A(Dysport)


The botulinum-A toxin group had a significantly higher bladder capacity than placebo at 6 (p<0.001) and 12 weeks (p=0.026) but not at 26 weeks (ns)VS (i)NNN (ii)NLow

VS very serious N none


No details of randomisation or allocation concealment, incomplete outcome reporting


Imprecision could not be assessed – no estimates of effect


Ehren et al. 200762

From: 8, Treatment to improve bladder storage

Cover of Urinary Incontinence in Neurological Disease
Urinary Incontinence in Neurological Disease: Management of Lower Urinary Tract Dysfunction in Neurological Disease.
NICE Clinical Guidelines, No. 148.
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