D.6What is the safety and efficacy of detrusor injections of botulinum toxin type A or B compared with a) usual care b) antimuscarinics in neurological disease?

Review Protocol - IND
PopulationNeurological disease
InterventionBotulinum toxin A and B
ComparisonUsual care
OutcomesIncreased bladder capacity
Residual urine
Frequency of voiding by day and night.
Number of incontinence episodes per week..
Quality of life.
Adverse events, including urinary tract infections, unscheduled hospital admissions, generalised muscle weakness
Treatment continuance.
Kidney function.
Search strategyThe databases to be searched are Medline, Embase, The Cochrane Library, CINAHL
All years.
Studies will be restricted to English language only
Search terms
The review strategyRCT’s

From: Appendix D, Review Protocols

Cover of Urinary Incontinence in Neurological Disease
Urinary Incontinence in Neurological Disease: Management of Lower Urinary Tract Dysfunction in Neurological Disease.
NICE Clinical Guidelines, No. 148.
National Clinical Guideline Centre (UK).
Copyright © 2012, National Clinical Guideline Centre.

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