C.10Review protocol – Thrombolytic therapy (PE)

Review questionWhat is the effectiveness of open surgical thromboectomy, combination of mechanical and pharmacological thrombolysis, pharmacological thrombolytic therapy and heparin to mange acute PE?
ObjectivesTo determine whether thrombolytic therapy is effective in managing PE.
Criteria for considering studies for the review
Study designSystematic reviews or randomised controlled trials that compare thrombolytic therapy to placebo or standard pharmacological treatment.
PopulationPatients with acute PE.
InterventionThrombolytic therapy with pharmacological treatment and mechanical thrombectomy with pharmacological treatment
ComparisonPharmacological treatment or placebo
OutcomesAll cause mortality, VTE related mortality, major bleeding, recurrent VTE, quality of life, chronic thromboembolic pulmonary hypertension, length of hospital stay, heparin induced thrombocytopenia
EqualitiesNone reported
How the information will be searched
Search strategy
The databases to be searched are Medline, Embase, The Cochrane Library and CINAHL.
Studies will be restricted to English language only
No date restriction will be applied. Databases will be searched from their date of origin.
The review strategyMeta-analysis will be conducted where possible.

Where possible perform sub-group analysis for:
  • the severity – massive PE, submassive PE
  • cancer patients

From: Appendix C, Review protocols

Cover of Venous Thromboembolic Diseases
Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing [Internet].
NICE Clinical Guidelines, No. 144.
National Clinical Guideline Centre (UK).
Copyright © 2012, National Clinical Guideline Centre.

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