PubMed Health. A service of the National Library of Medicine, National Institutes of Health.

National Clinical Guideline Centre (UK). Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing [Internet]. London: Royal College of Physicians (UK); 2012 Jun. (NICE Clinical Guidelines, No. 144.)

Appendix DLiterature search strategies

Search strategies used for the venous thromboembolic diseases guideline are outlined below and were run as per the NICE Guidelines Manual 2009 http://www.nice.org.uk/media/5F2/44/The_guidelines_manual_2009_-_All_chapters.pdf.

Searches for the clinical reviews were run in Medline (OVID), Embase (OVID), the Cochrane Library and Cinahl (EBSCO). Usually, searches were constructed in the following way:

  • A PICO format was used for intervention searches where population (P) terms were combined with Intervention (I) and sometimes Comparison (C) terms. An intervention can be a drug, a procedure or a diagnostic test. Outcomes (O) are rarely used in search strategies for interventions. Search Filters were also added to the search where appropriate.
  • A PEO format was used for prognosis searches where population (P) terms were combined with exposure (E) terms and sometimes outcomes (O). Search filters were added to the search where appropriate.

Searches for patient education were run in Medline (Ovid), Embase (Ovid), Cinahl (EBSCO) and PsychINFO (Ovid). Searches were constructed by adding a patient education search filter to the population terms.

Searches for the health economic reviews were run in Medline (Ovid), Embase (Ovid), the NHS Economic Evaluations Database (NHS EED), the Health Technology Assessment (HTA) database and the Health Economic Evaluation Database (HEED). Searches in NHS EED, HTA and HEED were constructed only using population terms. For Medline and Embase an economic filter (instead of a study type filter) was added to the same clinical search strategy.

All searches were run up to 1st August 2011 unless otherwise stated. Any studies added to the databases after this date were not included unless specifically stated in the text.

The search strategies are presented below in the following order:

Section D.1Population terms by database. The same searches were used for all questions as indicated and for both clinical and health economic searches.
Section D.2Study filter terms by database. These include filters for epidemiological study designs, health economic studies, quality of life studies and patient education.
Section D.3Searches run for specific questions with the intervention or exposure terms by database. Order as presented in guideline
D.3.1Diagnosis – DVT
D.3.2Diagnosis – PE
D.3.3Diagnosis – clinical scores
D.3.4Pharmacological interventions
D.3.5Pharmacological interventions – duration
D.3.6Thrombolysis
D.3.7Mechanical interventions – vena caval filters
D.3.8Mechanical interventions – stockings
D.3.9Patient education
D.3.10Self monitoring and management
D.3.11Cancer screening
D.3.12Thrombophilia screening
Section D.4Economics search

D.1. Population search strategies

Medline search terms

Deep vein thrombosis (DVT)

1Thromboembolism/ or Thrombophlebitis/ or Venous Thrombosis/
2(((venous or vein) adj (thrombosis or thrombus or thromboembolism)) or (dvt or vte) or thrombophlebitis).ti,ab.
3or/1–2

Pulmonary embolism (PE)

1Pulmonary Embolism/
2((pulmonary or lung) adj6 (embolism or emboli)).ti,ab.
3or/1–2

Embase search terms

Deep vein thrombosis (DVT)

1Thromboembolism/ or Venous Thromboembolism/ or Vein Thrombosis/ or Deep Vein Thrombosis/ or Leg Thrombosis/ or Postoperative Thrombosis/ or Thrombophlebitis/
2(((venous or vein) adj (thrombosis or thrombus or thromboembolism)) or (dvt or vte) or thrombophlebitis).ti,ab.
3or/1–2

Pulmonary embolism (PE)

1Lung Embolism/
2((pulmonary or lung) adj6 (embolism or emboli)).ti,ab.
3or/1–2

Cinahl search terms

Deep vein thrombosis (DVT)

S1Mh Thromboembolism or mh Thrombophlebitis or mh Venous Thrombosis or thrombophlebitis or venous n thrombosis or venous n thrombus or venous n thromboembolism or vein n thrombosis or vein n thrombus or vein n thromboembolism or vte or dvt

Pulmonary embolism (PE)

S1mh pulmonary embolism or pulmonary n6 embolism or pulmonary n6 emboli or lung n6 embolism or lung n6 emboli

Cochrane search terms

Deep vein thrombosis (DVT)

#1MeSH descriptor Thromboembolism, this term only
#2MeSH descriptor Thrombophlebitis, this term only
#3MeSH descriptor Venous Thrombosis, this term only
#4(((venous or vein) NEAR (thrombosis or thrombus or thromboembolism)) or (dvt or vte) or thrombophlebitis):ti,ab,kw
#5(#1 OR #2 OR #3 OR #4)

Pulmonary embolism (PE)

#1MeSH descriptor Pulmonary Embolism, this term only
#2((pulmonary or lung) NEAR/6 (embolism or emboli)):ti,ab,kw
#3(#1 OR #2)

D.2. Study filter search terms

D.2.1. Systematic review search terms

Medline search terms

1meta-analysis/
2(metaanalys$ or meta-analys$ or meta analys$).tw.
3exp “review literature”/
4(systematic$ adj3 (review$ or overview$)).tw.
5(selection criteria or data extraction).ab. and review.pt.
6(cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or cinhal or science citation index or bids or cancerlit).ab.
7(reference list$ or bibliograph$ or hand search$ or hand-search$ or manual search$ or relevant journals).ab.
8or/1–7
9(comment or letter or editorial).pt.
10animal/ not human/
11or/9–10
128 not 11

Embase search terms

1meta analysis/
2(metaanalys$ or meta-analys$ or meta analys$).tw.
3systematic review/
4(systematic$ adj3 (review$ or overview$)).tw.
5(selection criteria or data extraction).ab. and Review.pt.
6(cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or cinhal or science citation index or bids or cancerlit).ab.
7(reference list$ or bibliograph$ or hand search$ or manual search$ or relevant journals).ab.
8or/1–7
9(letter or editorial).pt.
10(exp animal/ or nonhuman/ or exp animal-experiment/) not exp human/
11or/9–10
128 not 11

D.2.2. Randomised controlled trials (RCTs) search terms

Medline search terms

1Randomized-Controlled-Trials/ or Random-Allocation/ or Double-Blind-Method/ or Single- Blind-Method/ or exp Clinical-Trials as topic/ or Cross-Over-Studies/ or Prospective-Studies/ or Placebos/
2(Randomized-Controlled-Trial or Clinical-Trial or Controlled-Clinical-Trial).pt.
3(((clinical or control or controlled) adj (study or trial)) or ((single or double or triple) adj (blind$3 or mask$3)) or (random$ adj (assign$ or allocat$ or group or grouped or patients or study or trial or distribut$)) or (crossover adj (design or study or trial)) or placebo or placebos).ti,ab.
4or/1–3
5((Case-Reports not Randomized-Controlled-Trial) or Letter or Historical-Article or Review-Of- Reported-Cases).pt.
6Animal/ not Human/
7or/5–6
84 not 7

Embase search terms

1Clinical-Trial/ or Randomized-Controlled-Trial/ or Randomization/ or Single-Blind-Procedure/ or Double-Blind-Procedure/ or Crossover-Procedure/ or Prospective-Study/ or Placebo/
2(((clinical or control or controlled) adj (study or trial)) or ((single or double or triple) adj (blind$3 or mask$3)) or (random$ adj (assign$ or allocat$ or group or grouped or patients or study or trial or distribut$)) or (crossover adj (design or study or trial)) or placebo or placebos).ti,ab.
3or/1–2
4Case-Study/ or Abstract-Report/ or Letter/ or (case adj report).tw.
5(exp Animal/ or Nonhuman/ or exp Animal-Experiment/) not exp Human/
6or/4–5
73 not 6

D.2.3. Diagnostic accuracy search terms

Medline search terms

1exp “Sensitivity and Specificity”/
2(sensitivity or specificity).tw.
3(predictive adj3 value$).tw.
4exp diagnostic errors/
5((false adj positiv$) or (false adj negativ$)).tw.
6(observer adj variation$).tw.
7(roc adj curve$).tw.
8(likelihood adj3 ratio$).tw.
9likelihood functions/
10*Thromboembolism/di, ra, ri, us
11*Thrombophlebitis/di, ra, ri, us
12*Venous Thrombosis/di, ra, ri, us
13or/1–12
14(comment or letter or editorial).pt.
15animal/ not human/
16or/14–15
1713 not 16

Embase search terms

1exp “sensitivity and specificity”/
2(sensitivity or specificity).tw.
3(predictive adj3 value$).tw.
4((false adj positiv$) or (false adj negativ$)).tw.
5(observer adj variation$).tw.
6(roc adj curve$).tw.
7(likelihood adj3 ratio$).tw.
8*Diagnostic Accuracy/
9*Thromboembolism/di
10*Thrombophlebitis/di
11*Venous Thrombosis/di
12or/1–11
13(letter or editorial).pt.
14(exp animal/ or nonhuman/ or exp animal-experiment/) not exp human/
15or/13–14
1612 not 15

D.2.4. Patient education search terms

Medline search terms

1Patients/ or Inpatients/ or Outpatients/
2Caregivers/ or exp Family/ or exp Parents/ or exp Legal-Guardians/
3(patients or carer$ or famil$).tw.
4or/1–3
5exp Information Services/ or exp Publications/ or Counseling/ or Directive Counseling/
64 and 5
7((patient or patients) adj3 (education or educate or educating or information or literature or leaflet$ or booklet$ or pamphlet$)).ti,ab.
8exp health education/ or Patient Education Handout/
9(phone$ or telephone$ or (information adj3 pack$)).ti,ab.
10or/6–9

Embase search terms

1Patient/ or Hospital patient/ or Outpatient/
2Caregiver/ or exp Family/ or exp Parent/
3(patients or carer$ or famil$).tw.
4or/1–3
5Information Service/ or Information center/ or Publication/ or Book/ or Counseling/ or Directive counseling/
64 and 5
7((patient or patients) adj3 (education or educate or educating or information or literature or leaflet$ or booklet$ or pamphlet$)).ti,ab.
8Patient information/ or Patient education/
9(phone$ or telephone$ or (information adj3 pack$)).ti,ab.
10or/6–9

Cinahl search terms

S1(MH “Patients”) OR (MH “Inpatients”) OR (MH “Outpatients”)
S2(MH “Parents+”) OR (MH “Caregivers”)
S3(MH “Family+”)
S4(MH “Guardianship, Legal”)
S5patient or patients or carer* or famil*
S6S1 or S2 or S3 or S4 or S5
S7(MH “Information Services+”)
S8(MH “Information Resources+”)
S9(MH “Counseling”)
S10S7 or S8 or S9
S11S6 and S10
S12patient n3 education or patient n3 educate or patient n3 educating or patient n3 information or patient n3 literature or patient n3 leaflet* or patient n3 booklet* or patient n3 pamphlet*
S13patients n3 education or patients n3 educate or patients n3 educating or patients n3 information or patients n3 literature or patients n3 leaflet* or patients n3 booklet* or patients n3 pamphlet*
S14(MH “Health Education+”)
S15phone* or telephone* or information n3 pack*
S16S11 or S12 or S13 or S15 or S15
S17PT letter or PT commentary or PT Editorial or mh animals
S18S16 not S17

Cochrane search terms

#1MeSH descriptor Patients, this term only
#2MeSH descriptor Inpatients, this term only
#3MeSH descriptor Outpatients, this term only
#4MeSH descriptor Caregivers, this term only
#5MeSH descriptor Family explode all trees
#6MeSH descriptor Parents explode all trees
#7MeSH descriptor Legal Guardians explode all trees
#8(patients or carer* or famil*):ti,ab,kw
#9(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8)
#10MeSH descriptor Information Services explode all trees
#11MeSH descriptor Publications explode all trees
#12MeSH descriptor Counseling, this term only
#13MeSH descriptor Directive Counseling, this term only
#14(#10 OR #11 OR #12 OR #13)
#15(#9 AND #14)
#16((patient or patients) NEAR/3 (education or educate or educating or information or literature or leaflet* or booklet* or pamphlet*)):ti,ab,kw
#17MeSH descriptor Health Education explode all trees
#18(phone* or telephone* or (information NEAR/3 pack*)):ti,ab,kw
#19(#15 OR #16 OR #17 OR #18)

PsychInfo search terms

1exp patients/
2caregivers/ or exp family/ or exp parents/ or exp guardianship/
3(patients or carer$ or famil$).tw.
4or/1–3
5exp information services/ or exp printed communications media/ or reading materials/ or exp counseling/
64 and 5
7((patient or patients) adj3 (education or educate or educating or information or literature or leaflet$ or booklet$ or pamphlet$)).ti,ab.
8client education/
9(phone$ or telephone$ or (information adj3 pack$)).ti,ab.
10or/6–9

D.2.5. Health economic and quality of life search terms

Medline search terms

1exp “costs and cost analysis”/
2economics/ or exp economics, hospital/ or exp economics, medical/ or economics, nursing/ or economics, pharmaceutical/
3exp “fees and charges”/ or exp budgets/
4budget$.tw.
5cost$.ti.
6(cost$ adj2 (effective$ or utilit$ or benefit$ or minimi$)).ab.
7(economic$ or pharmacoeconomic$ or pharmaco-economic$).ti.
8(price$ or pricing$).tw.
9(financial or finance or finances or financed).tw.
10(fee or fees).tw.
11(value adj2 (money or monetary)).tw.
12value of life/ or quality adjusted life year/
13quality adjusted life.tw.
14(qaly$ or qald$ or qale$ or qtime$).tw.
15disability adjusted life.tw.
16daly$.tw.
17Health Status Indicators/
18(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
19(sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
20(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
21(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw.
22(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
23(euroqol or euro qol or eq5d or eq 5d).tw.
24(hql or hqol or h qol or hrqol or hr qol).tw.
25(hye or hyes).tw.
26health$ year$ equivalent$.tw.
27health utilit$.tw.
28(hui or hui1 or hui2 or hui3).tw.
29disutilit$.tw.
30rosser.tw.
31(quality of wellbeing or quality of well being or qwb).tw.
32willingness to pay.tw.
33standard gamble$.tw.
34time trade off.tw.
35time tradeoff.tw.
36tto.tw.
37or/1–36
38(letter or editorial or comment).pt.
3937 not 38

Embase search terms

1exp economic aspect/
2cost$.ti.
3(cost$ adj2 (effective$ or utilit$ or benefit$ or minimi$)).ab.
4(economic$ or pharmacoeconomic$ or pharmaco-economic$).ti.
5(price$ or pricing$).tw.
6(financial or finance or finances or financed).tw.
7(fee or fees).tw.
8(value adj2 (money or monetary)).tw.
9quality adjusted life year/
10quality adjusted life.tw.
11(qaly$ or qald$ or qale$ or qtime$).tw.
12disability adjusted life.tw.
13daly$.tw.
14(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
15(sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
16(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
17(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw.
18(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
19(euroqol or euro qol or eq5d or eq 5d).tw.
20(hql or hqol or h qol or hrqol or hr qol).tw.
21(hye or hyes).tw.
22health$ year$ equivalent$.tw.
23health utilit$.tw.
24(hui or hui1 or hui2 or hui3).tw.
25disutilit$.tw.
26rosser.tw.
27(quality of wellbeing or quality of well being or qwb).tw.
28willingness to pay.tw.
29standard gamble$.tw.
30(time trade off or time tradeoff or tto).tw.
31or/1–30
32(comment or letter or editorial).pt.
3331 not 32

D.3. Searches by specific questions

D.3.1. Diagnosis – DVT

Searches for the following two questions were run as one search:

  • In people with suspected DVT, what is the effectiveness of ultrasound in ruling out DVT?
  • In people with suspected DVT, what is the effectiveness of D-dimer in ruling out DVT?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVTDiagnostic tests: ultrasound, venography, D-dimerDiagnosis or SRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Diagnostic test search terms

Medline search terms

1ultrasonography/ or ultrasonography, doppler/ or exp ultrasonography, doppler, duplex/ or exp ultrasonography, doppler, pulsed/
2(ultrasound$ or ultrason$ or sonograph$).ti,ab.
3phlebography/
4(venograph$ or phlebograph$).ti,ab.
5Fibrin Fibrinogen Degradation Products/
6(D-dimer or d dimer).ti,ab.
7(label$ adj2 (fibrogen or fibrinogen)).ti,ab.
8((wells or Geneva or clinical) adj score$).ti,ab.
9or/1–8

Embase search terms

1echography/ or doppler echography/
2(ultrasound$ or ultrason$ or sonograph$).ti,ab.
3exp phlebography/
4(venograph$ or phlebograph$).ti,ab.
5fibrin degradation product/
6D dimer/
7(D-dimer or d dimer).ti,ab.
8(label$ adj2 (fibrogen or fibrinogen)).ti,ab.
9((wells or Geneva or clinical) adj score$).ti,ab.
10or/1–9

Cinahl search terms

S1mh ultrasonography or mh “ultrasonography, doppler” or MH “Ultrasonography, Doppler, Duplex+” or mh “ultrasonography, doppler, pulsed+” or ultrasound* or ultrason* or sonograph*
S2mh phlebography or venograph* or phlebograph*
S3mh “Fibrin Fibrinogen Degradation Products” or D-dimer or d dimer or label* n2 fibrogen or label* n2 fibrinogen
S4wells n1 score* or Geneva n1 score* or clinical n1 score*
S5S1 or S2 or S3 or S4

Cochrane search terms

#1MeSH descriptor Ultrasonography, this term only
#2MeSH descriptor Ultrasonography, Doppler, this term only
#3MeSH descriptor Ultrasonography, Doppler, Duplex explode all trees
#4MeSH descriptor Ultrasonography, Doppler, Pulsed explode all trees
#5(ultrasound* or ultrason* or sonograph*):ti,ab,kw
#6MeSH descriptor Phlebography, this term only
#7(venograph* or phlebograph*):ti,ab,kw
#8MeSH descriptor Fibrin Fibrinogen Degradation Products, this term only
#9(D-dimer or d dimer):ti,ab,kw
#10(label* NEAR/2 (fibrogen or fibrinogen)):ti,ab,kw
#11((wells or Geneva or clinical) NEAR score*):ti,ab,kw
#12(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11)

D.3.2. Diagnosis - PE

Searches for the following two questions were run as one search:

  • In people with suspected PE, what is the effectiveness of CT scan in ruling out PE?
  • In people with suspected PE, what is the effectiveness of ventilation perfusion scans in ruling out PE?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
PEDiagnostic tests: CT scan, ventilation perfusion scan, lung angiography, echocardiology, autopsyDiagnosis or SRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Diagnostic test search terms

Medline search terms

1tomography, x-ray computed/ or exp cone-beam computed tomography/ or exp tomography, spiral computed/
2(ct or compute$ tomograph$ or compute$-tomograph$ or cat).ti,ab.
3Angiography/
4(((pulmonary or lung$) adj3 angiograph$) or ctpa).ti,ab.
5exp Echocardiography/
6echocardiograph$.ti,ab.
7Autopsy/
8autops$.ti,ab.
9Perfusion Imaging/
10Ventilation-Perfusion Ratio/
11((vq or v-q or ventilation perfusion or ventilation-perfusion) adj1 (scan$ or imaging$ or scintigraph$)).ti,ab.
12or/1–11

Embase search terms

1computer assisted tomography/ or cone beam computed tomography/ or spiral computer assisted tomography/
2(ct or compute$ tomograph$ or compute$-tomograph$ or cat).ti,ab.
3lung angiography/
4(((pulmonary or lung$) adj3 angiograph$) or ctpa).ti,ab.
5exp echocardiography/
6echocardiograph$.ti,ab.
7autopsy/
8autops$.ti,ab.
9lung ventilation perfusion ratio/
10lung scintiscanning/
11((vq or v-q or ventilation perfusion or ventilation-perfusion) adj1 (scan$ or imaging$ or scintigraph$)).ti,ab.
12or/1–11

Cinahl search terms

S1mh “tomography, x-ray computed” or mh “cone-beam computed tomography+” or mh “tomography, spiral computed+” or compute* tomograph* or cat or compute*-tomograph* or “ct”
S2mh Angiography or pulmonary n3 angiograph* or lung* n3 angiograph* or ctpa or mh Echocardiography+ or echocardiograph* or mh Autopsy or autops*
S3scan* n1 vq or scan* n1 v-q or scan* n1 ventilation perfusion or scan* n1 ventilation-perfusion or imaging* n1 vq or imaging* n1 v-q or imaging* n1 ventilation perfusion or imaging* n1 ventilation-perfusion or scintigraph* n1 vq or scintigraph* n1 v-q or scintigraph* n1 ventilation perfusion or scintigraph* n1 ventilation-perfusion
S4S1 or S2 or S3

Cochrane search terms

#1MeSH descriptor Tomography, X-Ray Computed, this term only
#2MeSH descriptor Cone-Beam Computed Tomography explode all trees
#3MeSH descriptor Tomography, Spiral Computed explode all trees
#4(ct or compute* tomograph* or compute*-tomograph* or cat):ti,ab,kw
#5MeSH descriptor Angiography, this term only
#6(((pulmonary or lung*) NEAR/3 angiograph*) or ctpa):ti,ab,kw
#7MeSH descriptor Echocardiography explode all trees
#8echocardiograph*:ti,ab,kw
#9MeSH descriptor Autopsy, this term only
#10autops*:ti,ab,kw
#11MeSH descriptor Perfusion Imaging, this term only
#12MeSH descriptor Ventilation-Perfusion Ratio, this term only
#13((vq or v-q or ventilation perfusion or ventilation-perfusion) NEAR (scan* or imaging* or scintigraph*)):ti,ab,kw
#14(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13)

D.3.3. Diagnosis – clinical scores

Searches for the following two questions were run as one search:

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PEClinical scoresDiagnosis or SRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Clinical scores search terms

Medline search terms

1((wells or Geneva or Wicki or Hyers or clinical) adj (scor$ or rule)).ti,ab.
2Charlotte rule.ti,ab.
3((probablilit$ or predict$) adj (scor$ or rule$)).ti,ab.
4((decision or diagnostic) adj (rule or rules)).ti,ab.
5(clinical adj assess$).ti,ab.
6scor$ system$.ti,ab.
7*Decision trees/
8*decision support techniques/
9*risk factors/
10or/1–10

Embase search terms

1((wells or Geneva or Wicki or Hyers or clinical) adj (scor$ or rul)).ti,ab.
2Charlotte rule.ti,ab.
3((probablilit$ or predict$) adj (scor$ or rule$)).ti,ab.
4(clinical adj assess$).ti,ab.
5((decision or diagnostic) adj (rule or rules)).ti,ab.
6scor$ system$.ti,ab.
7*“decision tree”/
8*decision support system/
9*risk factor/
10*scoring system/
11or/1–11

Cinahl search terms

S1wells n1 scor* or wells n1 rule or Geneva n1 scor* or Geneva n1 rule or Wicki n1 scor* or Wicki n1 rule or Hyers n1 scor* or Hyers n1 rule or clinical n1 scor* or clinical n1 rule or Charlotte rule or probablilit* n1 scor* or predict* n1 scor* or probablilit* n1 rule* or predict* n1 rule* or clinical n1 assess* or scor* system* or decision n1 rule or decision n1 rules or diagnostic n1 rule or diagnostic n1 rules
S2(MM “Decision Trees”)
S3(MM “decision support techniques”) or mm “risk factors”
S4S1 or S2 or S3

Cochrane search terms

#1((wells or Geneva or Wicki or Hyers or clinical) NEAR scor*):ti,ab,kw
#2Charlotte rule:ti,ab,kw
#3((probablilit* or predict*) NEAR (scor* or rule*)):ti,ab,kw
#4(clinical NEAR assess*):ti,ab,kw
#5scor* system*:ti,ab,kw
#6MeSH descriptor Decision Trees, this term only
#7MeSH descriptor Decision Support Techniques, this term only
#8((decision or diagnostic) NEAR (rule or rules)):ti,ab,kw
#9(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8)

D.3.4. Pharmacological Interventions

Searches for the following two questions were run as one search:

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PEPharmacological interventionsSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Pharmacological interventions search terms

Medline search terms

1exp Heparin/
2(heparin$ or ufh or ldh or lwmh).ti,ab.
3(calciparine or monoparin or multiparin).ti,ab.
4(danaparoid or orgaran).ti,ab.
5(Bemiparin or Zibor or Dalteparin or Fragmin or Enoxaparin or Clexane or Lovenox or Tinzaparin or Innohep or antixarin or CY 222 or embolex or monoembolex or Ardeparin or Certoparin or Nadroparin or Fraxiparene or Parnaparin or Reviparin or Tedelparin).ti,ab.
6(pentasaccharide or pentasaccharides or indirect factor xa inhibit$).ti,ab.
7(fondaparinux or idraparinux or arixtra).ti,ab.
8(anticoagula$ or anti coagula$).ti,ab.
9(warfarin or acenocoumarol or nicoumalone or sinthrome or phenindione or dicoumarol or coumadin or phenprocoumon or phepromaron or ethyl-biscoumacetate).ti,ab.
10vitamin K antagonist$.ti,ab.
11exp 4-Hydroxycoumarins/
12Anticoagulants/
13Phenindione/
14or/1–13
15((prevention or prophylaxis or thromboprophylaxis) not (treat$ or manag$ or recurr$ or second$)).ti.
1614 not 15

Embase search terms

1exp heparin derivative/
2(heparin$ or ufh or ldh or lwmh).ti,ab.
3(calciparine or monoparin or multiparin).ti,ab.
4(danaparoid or orgaran).ti,ab.
5(Bemiparin or Zibor or Dalteparin or Fragmin or Enoxaparin or Clexane or Lovenox or Tinzaparin or Innohep or antixarin or CY 222 or embolex or monoembolex or Ardeparin or Certoparin or Nadroparin or Fraxiparene or Parnaparin or Reviparin or Tedelparin).ti,ab.
6pentasaccharide/
7(pentasaccharide or pentasaccharides or indirect factor xa inhibit$).ti,ab.
8(fondaparinux or idraparinux or arixtra).ti,ab.
9(anticoagula$ or anti coagula$).ti,ab.
10(warfarin or acenocoumarol or nicoumalone or sinthrome or phenindione or dicoumarol or coumadin or phenprocoumon or phepromaron or ethyl-biscoumacetate).ti,ab.
11vitamin K antagonist$.ti,ab.
12exp coumarin anticoagulant/
13anticoagulant agent/
14antivitamin K/
15phenindione/
16or/1–15
17((prevention or prophylaxis or thromboprophylaxis) not (treat$ or manag$ or recurr$ or second$)).ti.
1816 not 17

Cinahl search terms

S1heparin* or ufh or ldh or lwmh or mh Heparin+ or calciparine or monoparin or multiparin or danaparoid or orgaran
S2Bemiparin or Zibor or Dalteparin or Fragmin or Enoxaparin or Clexane or Lovenox or Tinzaparin or Innohep or antixarin or CY 222 or embolex
S3monoembolex or Ardeparin or Certoparin or Nadroparin or Fraxiparene or Parnaparin or Reviparin or Tedelparin
S4pentasaccharide or pentasaccharides or indirect factor xa inhibit* or fondaparinux or idraparinux or arixtra or anticoagula* or anti coagula* or vitamin K antagonist*
S5warfarin or acenocoumarol or nicoumalone or sinthrome or phenindione or dicoumarol or coumadin or phenprocoumon or phepromaron and ethyl-biscoumacetate
S6mh 4-Hydroxycoumarins+ or mh Anticoagulants or mh Phenindione
S7S1 or S2 or S3 or S4 or S5 or S6
S8TI prevention or TI prophylaxis or TI thromboprophylaxis
S9TI treat* or TI manag* or TI recurr* or TI second*
S10S8 not S9
S11S7 not S10

Cochrane search terms

#1(heparin* or ufh or ldh or lwmh):ti,ab,kw
#2MeSH descriptor Heparin explode all trees
#3(calciparine or monoparin or multiparin):ti,ab,kw
#4(danaparoid or orgaran):ti,ab,kw
#5(Bemiparin or Zibor or Dalteparin or Fragmin or Enoxaparin or Clexane or Lovenox or Tinzaparin or Innohep or antixarin or CY 222 or embolex or monoembolex or Ardeparin or Certoparin or Nadroparin or Fraxiparene or Parnaparin or Reviparin or Tedelparin):ti,ab,kw
#6(pentasaccharide or pentasaccharides or indirect factor xa inhibit*):ti,ab,kw
#7(fondaparinux or idraparinux or arixtra):ti,ab,kw
#8(anticoagula* or anti coagula*):ti,ab,kw
#9(warfarin or acenocoumarol or nicoumalone or sinthrome or phenindione or dicoumarol or coumadin or phenprocoumon or phepromaron or ethyl-biscoumacetate):ti,ab,kw
#10(vitamin K antagonist*):ti,ab,kw
#11MeSH descriptor 4-Hydroxycoumarins explode all trees
#12MeSH descriptor Anticoagulants, this term only
#13MeSH descriptor Phenindione, this term only
#14(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13)
#15((prevention or prophylaxis or thromboprophylaxis) not (treat* or manag* or recurr* or second*)):ti
#16(#14 AND NOT #15)

D.3.5. Pharmacological Interventions – duration

What is the optimal treatment duration for pharmacological interventions?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PEPharmacological InterventionsDurationSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Duration search terms

Medline search terms

1Drug Administration Schedule/
2(time or duration$).ti,ab.
3Time Factors/
4or/1–3

Embase search terms

1treatment duration/
2(time or duration$).ti,ab.
3or/1–2

Cinahl search terms

S1(MH “Drug Administration Schedule”)
S2(MH “Time Factors”)
S3time or duration*
S4S1 or S2 or S3

Cochrane search terms

#1(time or duration*):ti,ab,kw
#2MeSH descriptor Drug Administration Schedule, this term only
#3MeSH descriptor Time Factors, this term only
#4(#1 OR #2 OR #3)

D.3.6. Thrombolysis

Searches for the following two questions were run as one search:

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PEThrombolysisSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Thrombolysis terms

Medline search terms

1exp Thrombolytic Therapy/
2thromboly$.ti,ab.
3fibrinoly$.ti,ab.
4Thrombectomy/
5thrombectom$.ti,ab.
6embolectomy/
7embolectom$.ti,ab.
8Streptokinase/
9(streptokinase or streptase).ti,ab.
10(plasminogen Activator$ or tpa or rt-pa).ti,ab.
11Tissue Plasminogen Activator/
12(alteplase or actilyse).ti,ab.
13Urokinase-Type Plasminogen Activator/
14(urokinase or syner-kinase or prourokinase).ti,ab.
15or/1–14

Embase search terms

1fibrinolytic therapy/
2thromboly$.ti,ab.
3fibrinoly$.ti,ab.
4exp thrombectomy/
5thrombectom$.ti,ab.
6embolectomy/
7embolectom$.ti,ab.
8alteplase/ or streptokinase/ or streptokinase derivative/ or tissue plasminogen activator/ or tissue plasminogen activator derivative/ or urokinase/
9(streptokinase or streptase).ti,ab.
10(plasminogen Activator$ or tpa or rt-pa).ti,ab.
11(alteplase or actilyse).ti,ab.
12(urokinase or syner-kinase or prourokinase).ti,ab.
13or/1–12

Cinahl search terms

S1(MH “Thrombolytic Therapy”)
S2thromboly* or fibrinoly*
S3(MH “Thrombectomy”) OR (MH “Embolectomy”)
S4thrombectom* or embolectom*
S5(MH “Streptokinase”)
S6streptokinase or streptase
S7(MH “Tissue Plasminogen Activator”)
S8plasminogen activator* or tpa or rt-pa
S9alteplase or actilyse
S10(MH “Urokinase”)
S11urokinase or syner-kinase or prourokinase
S12S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11

Cochrane search terms

#1MeSH descriptor Thrombolytic Therapy explode all trees
#2(thromboly* or fibrinoly*):ti,ab,kw
#3MeSH descriptor Thrombectomy, this term only
#4thrombectom*:ti,ab,kw
#5MeSH descriptor Streptokinase, this term only
#6(streptokinase or streptase):ti,ab,kw
#7(plasminogen Activator* or tpa or rt-pa):ti,ab,kw
#8MeSH descriptor Tissue Plasminogen Activator, this term only
#9(alteplase or actilyse):ti,ab,kw
#10MeSH descriptor Urokinase-Type Plasminogen Activator, this term only
#11(urokinase or syner-kinase or prourokinase):ti,ab,kw
#12embolectom*:ti,ab,kw
#13MeSH descriptor Embolectomy, this term only
#14(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13)

D.3.7. Mechanical Interventions – vena caval filters

What is the effectiveness of vena caval filters to manage venous thromboembolic diseases in people that are unable to have pharmacological treatment?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PEVena cava filtersSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Vena cava filter search terms

Medline search terms

1Vena Cava Filters/
2((((ivc or vena) adj (cava or caval)) or greenfield) adj2 (filter or filters)).ti,ab.
3or/1–2

Embase search terms

1vena cava filter/
2((((ivc or vena) adj (cava or caval)) or greenfield) adj2 (filter or filters)).ti,ab.
3or/1–2

Cinahl search terms

S1(MH “Vena Cava Filters”)
S2ivc cava n2 filter or ivc cava n2 filters or ivc caval n2 filter or ivc caval n2 filters or vena cava n2 filter or vena cava n2 filter3 or vena caval n2 filter or vena caval n2 filters or greenfield n2 filter or greenfield n2 filters
S3S1 or S2

Cochrane search terms

#1MeSH descriptor Vena Cava Filters, this term only
#2((((ivc or vena) NEAR (cava or caval)) or greenfield) NEAR/2 (filter or filters)):ti,ab,kw
#3(#1 OR #2)

D.3.8. Mechanical interventions – stockings

What is the effectiveness of stockings to prevent post thrombotic syndrome in people with venous thromboembolic diseases?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PEStockingsSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Stockings search terms

Medline search terms

1bandages/ or stockings, compression/
2(stocking$ or hose or tights or bandage$).ti,ab.
3or/1–2

Embase search terms

1compression bandage/ or compression garment/
2(stocking$ or hose or tights or bandage$).ti,ab.
3or/1–2

Cinahl search terms

S1(MH “Compression Garments”)
S2stocking* or hose or tights or bandage*
S3S1 or S2

Cochrane search terms

#1MeSH descriptor Bandages, this term only
#2MeSH descriptor Stockings, Compression, this term only
#3(stocking* or hose or tights or bandage*):ti,ab,kw
#4(#1 OR #2 OR #3)

D.3.9. Patient education

Does provision of information and support about management of VTE improve patient outcomes?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PE or vitamin KPatient educationSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Medline search terms – vitamin K

1vitamin k.ti,ab.
2exp Vitamin K/
3or/1–2

Embase search terms – vitamin K

1antivitamin K/
2vitamin k.ti,ab.
3or/1–2

Cinahl search terms – vitamin K

Cochrane search terms – vitamin K

#1vitamin k:ti,ab,kw
#2MeSH descriptor Vitamin K explode all trees
#3(#1 OR #2)

PsychInfo search terms – DVT or PE or vitamin K

1thromboses/ or embolisms/
2(((venous or vein) adj (thrombosis or thrombus or thromboembolism)) or (dvt or vte) or (((pulmonary or lung) adj3 (embolism or emboli)) or thrombophlebitis)).ti,ab.
3vitamin k.ti,ab.
4or/1–3

D.3.10. Self-management and self-monitoring for patients treated with vitamin k antagonist

What is the effectiveness of self monitoring compared to hospital/GP testing for long-term pharmacological treatments?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PEPharmacological interventionsSelf monitoringSRs or RCTs (Medline and Embase only)2007 to 01/08/2011

Self monitoring terms

Medline search terms

1self care/ or self administration/
2Point-of-Care Systems/
3((self or home$ or patient$) adj (monit$ or manage$ or test$ or adjust$ or measur$)).ti,ab.
4(point of care or (home adj2 kit$)).ti,ab.
5((self or home$ or patient$) adj1 (monit$ or manage$ or test$ or adjust$ or measur$)).ti,ab.
6or/1–4

Embase search terms

1home monitoring/ or self monitoring/
2home diagnostic test/
3self care/
4drug self administration/
5self control/
6((self or home$ or patient$) adj1 (monit$ or manage$ or test$ or adjust$ or measur$)).ti,ab.
7(point of care or (home adj2 kit$)).ti,ab.
8or/1–7

Cinahl search terms

S1(MH “Self Care”) OR (MH “Self Administration”)
S2(MH “Point-of-Care Testing”)
S3point of care or point-of-care or home n2 kit* or self n1 monit* or self n1 manage* or self n1 test* or self n1 adjust* or self n1 measur*
S4home* n1 monit* or home* n1 manage* or home* n1 test* or patient* n1 monit* or patient* n1 manage* or patient* n1 test* or patient* n1 adjust* or patient* n1 measur* or home* n1 adjust* or home* n1 measur*
S5S1 or S2 or S3 or S4

Cochrane search terms

#1MeSH descriptor Self Care, this term only
#2MeSH descriptor Self Administration, this term only
#3MeSH descriptor Point-of-Care Systems, this term only
#4((self or home* or patient*) NEAR (monit* or manage* or test* or adjust* or measur*)):ti,ab,kw
#5(point of care or (home NEAR/2 kit*)):ti,ab,kw
#6(#1 OR #2 OR #3 OR #4 OR #5)

D.3.11. Investigation for cancer

Does screening for cancer in patients with spontaneous venous thromboembolism (DVT or PE) improve patient outcomes (morbidity and mortality)?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PECancer screeningSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Cancer screening terms

Medline search terms

1exp *neoplasms/di
2((cancer$ or neoplasm$ or malignan$) adj2 (screen$ or test$ or diagnos$ or detect$ or occult or search$)).ti,ab.
3“Early Detection of Cancer”/
4or/1–3

Embase search terms

1((cancer$ or neoplasm$ or malignan$) adj2 (screen$ or test$ or diagnos$ or detect$ or occult or search$)).ti,ab.
2cancer screening/
3*neoplasm/di
4occult cancer/di
5or/1–4

Cinahl search terms

S1(MH “Early Detection of Cancer”)
S2(MM “Neoplasms+/DI”)
S3cancer* n2 screen* or cancer* n2 test* or cancer* n2 diagnos* or cancer* n2 detect* or cancer* n2 occult or cancer* n2 search* or neoplasm* n2 screen* or neoplasm* n2 test* or neoplasm* n2 diagnos* or neoplasm* n2 detect* or neoplasm* n2 occult or neoplasm* n2 search*
S4malignan* n2 screen* or malignan* n2 test* or malignan* n2 diagnos* or malignan* n2 detect* or malignan* n2 occult or malignan* n2 search*
S5S1 or S2 or S3 or S4

Cochrane search terms

#1MeSH descriptor Early Detection of Cancer, this term only
#2MeSH descriptor Neoplasms explode all trees with qualifier: DI
#3((cancer* or neoplasm* or malignan*) NEAR/2 (screen* or test* or diagnos* or detect* or occult or search*)):ti,ab,kw
#4(#1 OR #2 OR #3)

D.3.12. Thrombophilia screening

Searches for the following two questions were run as one search:

  • What is the effectiveness of thrombophilia testing in preventing recurrence of a venous thromboembolic event?
  • Does thrombophilia testing improve the outcomes of 1st degree relatives of people who had thromboembolic disease and thrombophilia?

Search constructed by combining the columns in the following table using the AND Boolean operator

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PE or familiyThrombophilia screeningSRs or RCTs (Medline and Embase only)No date restriction. Search run up to 01/08/2011

Medline search terms - family

1(cascade or first-degree or family or relatives).ti,ab.

Medline search terms – thrombophilia screening

1(thrombophil$ or hypercoagul$).ti,ab.
2Thrombophilia/
3or/1–2
4activated protein c resistance/or antithrombin iii deficiency/or protein c deficiency/
5Protein S Deficiency/
6exp Factor VIII/
7exp Antibodies, Antiphospholipid/
8prothrombin/
9beta 2-Glycoprotein I/
10“Methylenetetrahydrofolate Reductase (NADPH2)”/
11((prothrombin adj (G20210A or “20210”)) or (protein C adj (deficienc$ or resistance)) or protein S deficienc$ or ((antithrombin or anti thrombin) adj deficienc$) or (factor adj (VIII or V leiden or II leiden or II G20210A)) or (lupus adj (coagulation inhibitor or anticoagulant)) or (antibod$ adj1 (antiphospholipid or anticardiolipin)) or at III or apc resistance or anti-beta2 glycoprotein or Methylenetetrahydrofolate reductase or mthfr).ti,ab.
12or/4–11
13exp Mass Screening/
14“diagnostic techniques and procedures”/or diagnostic tests, routine/
15Genetic Testing/
16(screen$ or test$).ti,ab.
17or/13–16
183 or 12
1918 and 17
20*contraceptives, oral/
21*hormone replacement therapy/
22*estrogen replacement therapy/
23(oral adj (contraceptive$ or contraception)).ti.
24((hormone replacement or estrogen or oestrogen) adj therap$).ti.
25((oestrogen or estrogen) adj replacement).ti.
26h?emophili$.ti.
27*hemophilia a/or *hemophilia b/
28or/20–27
2919 not 28

Embase search terms - family

1(cascade or first-degree or family or relatives).ti,ab.

Embase search terms – thrombophilia screening

1(thrombophil$ or hypercoagul$).ti,ab.
2thrombophilia/
3or/1–2
4((prothrombin adj (G20210A or “20210”)) or (protein C adj (deficienc$ or resistance)) or protein S deficienc$ or ((antithrombin or anti thrombin) adj deficienc$) or (factor adj (VIII or V leiden or II leiden or II G20210A)) or (lupus adj (coagulation inhibitor or anticoagulant)) or (antibod$ adj1 (antiphospholipid or anticardiolipin)) or at III or apc resistance or anti-beta2 glycoprotein or Methylenetetrahydrofolate reductase or mthfr).ti,ab.
5activated protein C resistance/
6protein c deficiency/or protein s deficiency/
7antithrombin iii deficiency/or blood clotting factor 5 deficiency/
8lupus anticoagulant/
9cardiolipin antibody/or phospholipid antibody/
10blood clotting factor 8/
11prothrombin/
12beta2 glycoprotein 1/
13“methylenetetrahydrofolate reductase (NADPH2)”/
14or/4–13
153 or 14
16(screen$ or test$).ti,ab.
17mass screening/
18diagnostic test/
19diagnostic procedure/
20genetic screening/
21or/16–20
2215 and 21
23*oral contraceptive agent/
24*hormone substitution/
25*estrogen therapy/
26(oral adj (contraceptive$ or contraception)).ti.
27((hormone replacement or estrogen or oestrogen) adj therap$).ti.
28((oestrogen or estrogen) adj replacement).ti.
29h?emophili$.ti.
30exp *hemophilia/
31or/23–30
3222 not 31

Cinahl search terms - family

S1cascade or first-degree or family or relatives

Cinahl search terms – thrombophilia screening

S1(MH “Blood Coagulation Factors”) or (MH “Antiphospholipid Syndrome”) or thrombophil* or hypercoagul* or prothrombin n1 G20210A or prothrombin n1 20210 or protein C n1 deficienc* or protein C n1 resistance or protein S deficienc* or antithrombin n1 deficienc* or anti thrombin n1 deficienc* or anti-beta2 glycoprotein
S2factor n1 VIII or factor n1 V leiden or factor n1 II leiden or factor n1 II G20210A or lupus n1 coagulation inhibitor or lupus n1 anticoagulant or antibod* n1 antiphospholipid or antibod* n1 anticardiolipin or at III or apc resistance or Methylenetetrahydrofolate reductase or mthfr
S3S1 or S2
S4(MH “Diagnostic Tests, Routine”) or (MH “Genetic Screening”) or screen* or test*
S5S3 and S4
S6(MM “Hemophilia”) or TI h?emophili* or TI oestrogen n1 replacement or TI estrogen n1 replacement or TI hormone replacement n1 therap* or TI estrogen n1 therap* or TI oestrogen n1 therap* or (MM “Hormone Replacement Therapy”) or TI oral n1 contraceptive* or TI oral n1 contraception or (MM “Contraceptives, Oral”)
S7S5 not S6

Cochrane search terms – family

#1(cascade or first-degree or family or relatives):ti,ab,kw

Cochrane search terms – thrombophilia screening

#1(thrombophil* or hypercoagul*):ti,ab,kw
#2MeSH descriptor Thrombophilia explode all trees
#3MeSH descriptor Factor VIII explode all trees
#4MeSH descriptor Antibodies, Antiphospholipid explode all trees
#5MeSH descriptor Prothrombin, this term only
#6MeSH descriptor beta 2-Glycoprotein I, this term only
#7MeSH descriptor Methylenetetrahydrofolate Reductase (NADPH2), this term only
#8((prothrombin NEAR (G20210A or “20210”)) or (protein C NEAR (deficienc* or resistance)) or protein S deficienc* or ((antithrombin or anti thrombin) NEAR deficienc*) or (factor NEAR (VIII or V leiden or II leiden or II G20210A)) or (lupus NEAR (coagulation inhibitor or anticoagulant)) or (antibod* NEAR (antiphospholipid or anticardiolipin)) or at III or apc resistance or anti-beta2 glycoprotein or Methylenetetrahydrofolate reductase or mthfr):ti,ab,kw
#9(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8)
#10MeSH descriptor Mass Screening explode all trees
#11MeSH descriptor Diagnostic Techniques and Procedures, this term only
#12MeSH descriptor Diagnostic Tests, Routine, this term only
#13MeSH descriptor Genetic Testing, this term only
#14(screen* or test*):ti,ab,kw
#15(#10 OR #11 OR #12 OR #13 OR #14)
#16(#9 AND #15)
#17MeSH descriptor Contraceptives, Oral explode all trees
#18MeSH descriptor Hormone Replacement Therapy explode all trees
#19(oral NEAR (contraceptive* or contraception)):ti
#20((hormone replacement or estrogen or oestrogen) NEAR therap*):ti
#21((oestrogen or estrogen) NEAR replacement):ti
#22h?emophili*:ti
#23MeSH descriptor Hemophilia A, this term only
#24MeSH descriptor Hemophilia B, this term only
#25(#17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24)
#26(#16 AND NOT #25)

D.4. Economics search

Economic searches were conducted in Medline, Embase, HEED and CRD for NHS EED and HTA.

PopulationIntervention/exposureComparisonStudy filter usedDate parameters
DVT or PE or thrombophiliaEconomic or quality of life (Medline and Embase onlyMedline and Embase 2010 to 01/08/2011
HEED, CRD EED and HTA no date restriction; search run up to 01/08/2011

Medline search terms

1Thromboembolism/or Thrombophlebitis/or Venous Thrombosis/or Pulmonary Embolism/or exp Thrombophilia/
2(((venous or vein) adj (thrombosis or thrombus or thromboembolism)) or (dvt or vte) or (((pulmonary or lung) adj6 (embolism or emboli)) or thrombophlebitis)).ti,ab.
3(thrombophilia$ or hypercoagulabilit$).ti,ab.
4or/1–3

Embase search terms

1Thromboembolism/or Venous Thromboembolism/or Vein Thrombosis/or Deep Vein Thrombosis/or Leg Thrombosis/or Postoperative Thrombosis/or Lung Embolism/or Thrombophlebitis/
2(((venous or vein) adj (thrombosis or thrombus or thromboembolism)) or (dvt or vte) or (((pulmonary or lung) adj6 (embolism or emboli)) or thrombophlebitis)).ti,ab.
3(thrombophilia$ or hypercoagulabilit$).ti,ab.
4thrombophilia/
5or/1–4

CRD search terms

#1MeSH Pulmonary Embolism
#2MeSH Venous Thrombosis
#3MeSH Thrombophilia
#4venous AND thromboembolism OR deep AND vein AND thrombosis OR dvt OR vte
#5pulmonary AND embolism OR pulmonary AND emboli OR lung AND embolism OR lung AND emboli
#6“thromboembolism” ORthrombophiliaORhypercoagulability
#7#1 OR #2 OR #3 OR #4 OR #5 OR #6

HEED search terms

1AX=venous thromboembolism OR vein thromboembolism OR venous thrombosis
2AX=venous thrombus OR vein thrombus OR dvt OR vte OR thrombophlebitis
3AX=thrombophilia* OR hypercoagulabilit* OR vein thrombosis
4AX=pulmonary embolism OR pulmonary emboli OR lung embolism OR lung emboli
5CS=1 OR 2 OR 3 OR 4
Copyright © 2012, National Clinical Guideline Centre.

Apart from any fair dealing for the purposes of research or private study, criticism or review, as permitted under the Copyright, Designs and Patents Act, 1988, no part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

The rights of National Clinical Guideline Centre to be identified as Author of this work have been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988.

Cover of Venous Thromboembolic Diseases
Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing [Internet].
NICE Clinical Guidelines, No. 144.
National Clinical Guideline Centre (UK).

NICE (National Institute for Health and Care Excellence)

PubMed Health Blog...

read all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...