Table K12Sensitivity Differences (PCA3 - PSAD) at PCA3 False positive rates (1 – Specificity)a from 20% to 80% in matched studies to identify positive biopsy men

Study/AuthorbYearNumber20%c30%c40%c50%c60%c70%c80%c
Wu9201210337 (- 8)45 (-14)67 (- 1)77 (3)82 (4)82 (- 3)82 (- 3)
de la Taille7201151657 (13)71 (15)77 (15)85 (12)89 (3)93 (3)95 (0)
Ochiai8201110574 (- 3)87 (3)92 (3)97 (9)98 (4)100 (0)100 (0)
Median72457 (- 3)71 (3)77 (3)85 (9)89 (4)93 (0)95 (0)
a

(PCA3 sensitivity – PSAD sensitivity) when (1-specificity) is held constant at values ranging from 20% to 80%.

b

Shaded rows indicate studies focusing on the ‘grey zone’ of tPSA.

c

Results presented as PCA3 sensitivity (difference PCA3 sensitivity - EVN sensitivity).

From: Appendix K, Summary of the Remaining Combined Analyses for KQ 1 and KQ 2

Cover of PCA3 Testing for the Diagnosis and Management of Prostate Cancer
PCA3 Testing for the Diagnosis and Management of Prostate Cancer [Internet].
Comparative Effectiveness Reviews, No. 98.
Bradley LA, Palomaki G, Gutman S, et al.

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