Should low-dose fluphenazine versus ultra low-dose fluphenazine be used for people who self-harm?

Quality assessmentNo. of patientsEffectQualityImportance
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsLow dose fluphenazineUltra low-dose fluphenazineRelative risk (95% CI)Absolute
Repetition – during 6 months after trial entry
1Randomised trialsNo serious limitations--Serious1None12/27 (44.4%)9/26 (34.6%)RR 1.28 (0.65 to 2.52)97 more per 1000 (from 121 fewer to 526 more)--
-34.6%97 more per 1000 (from 121 fewer to 526 more)

Total sample size is smaller than 300.

From: Appendix 17, GRADE evidence profiles

Cover of Self-Harm: Longer-Term Management
Self-Harm: Longer-Term Management.
NICE Clinical Guidelines, No. 133.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2012.
Copyright © 2012, The British Psychological Society & The Royal College of Psychiatrists.

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