Table 102Deterministic base-case cost–utility results

Independent LOSVAS-dependent LOS
Single complication rate
(Scenario 1A)
Dynamic Complications
(Scenario 1B)
Single complication rate
(Scenario 2A)
Dynamic Complications
(Scenario 2B)
PlaceboLMWHΔPlaceboLMWHΔPlaceboLMWHΔPlaceboLMWHΔ
Costs
Acute episode:
  Inpatient care£5,524£3,355−£2,169£5,507£3,245−£2,262£1,067£686−£381£853£451−£402
  LMWH£0.00£68.27£68.27£0.00£66.21£66.21£0.00£17.05£17.05£0.00£12.57£12.57
  Morphine£26.00£3.30−£22.70£26.00£3.30−£22.70£23.16£14.53−£8.63£23.16£14.53−£8.63
  Subtotal£5,550£3,427−£2,124£5,533£3,314−£2,218£1,090£717−£373£876£478−£398
 Long-term costs:
  Stroke rehabilitation£532.69£532.69£0.00£158.47£72.15−£86.31£532.69£532.69£0.00£72.96£22.72−£50.24
Total£6,083£3,959−£2,124£5,691£3,386−£2,305£1,623£1,250−£373£949£500−£448
Effects
 Episodes of ACS6.26%6.26%1.86%0.85%6.26%6.26%0.86%0.27%
Strokes0.23%0.23%0.07%0.03%0.23%0.23%0.03%0.01%
 Deaths0.18%0.18%0.06%0.03%0.18%0.18%0.03%0.01%
 Mean LOS (days)12.1257.36312.0867.1222.3421.5051.8710.989
 QALYs:
  Acute episode0.0630.0640.0010.0630.0650.0010.0630.0640.0010.0640.0650.001
  Subsequent LE (discounted)13.02913.0290.00013.04013.0420.00313.02913.0290.00013.04213.0440.001
Total13.09113.0930.00113.10313.1070.00413.09113.0930.00113.10613.1080.003
ICERLMWH dominatesLMWH dominatesLMWH dominatesLMWH dominates
Incremental NMB:
 WTP=£20, 000/QALY£2,148.15£2,382.79£396.66£503.71
 WTP=£30, 000/QALY£2,160.27£2,421.84£408.58£531.35

ACS = acute chest syndrome; ICER = incremental cost-effectiveness ratio; LE = life expectancy; LMWH = low-molecular-weight heparin; LOS = length of (hospital) stay; NMB = net monetary benefit; QALY = quality-adjusted life-years; VAS = visual analogue scale

From: Appendix F, Full health economic report

Cover of Sickle Cell Acute Painful Episode
Sickle Cell Acute Painful Episode: Management of an Acute Painful Sickle Cell Episode in Hospital.
NICE Clinical Guidelines, No. 143.
Centre for Clinical Practice at NICE (UK).
Copyright © 2012, National Institute for Health and Clinical Excellence.

All rights reserved. This material may be freely reproduced for educational and not-for-profit purposes. No reproduction by or for commercial organisations, or for commercial purposes, is allowed without the express written permission of NICE.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.