GRADE profile 3Use of required referral

Study characteristicsSummary of findings
No. of studiesLimitationInconsistencyIndirectnessOther considerationAnalysisQuality
Referral rate and number of potential donors
1 study

1 × observational study-[M]
S (a)NANo seriousS (c)Low
2006–72007–8
NumberHeart beating donorsNon-heart beating donorsHeart beating donorsNon-heart beating donors
Referred21731
Accepted1167

There was an increase in referral rate.
There was an increase in the number of potential donors referred to the OPO representative.
Referral rate and number of potential donors
5 studies

4 × observational studies-[H], [Hi], [R], and [S]

1 × retrospective study-[B]
S (a)NAS (b)S (c)There was an increase in referral rate of between 56% to 450%

There was an increase in the number of potential donors referred to the OPO representative of between 3% and 80%
Very low
Number of donors
6 studies

3 × observational studies-[S], [R], and [Sh]

3 × retrospective studies-[B], [D], and [G]
S (a)NAS (b)S (c)Studies showed that there was an increase in the number of donors of between 24% and 275% from potential donors.Very low
Number of organs retrieved per donor
1 study

1 × observational study-[S]
S (a)NAS (b)S (c)A study showed that there was an increase of 312% for the number of organs retrieved per donor.Very low
Number of organs retrieved per donor
1 study

1 × retrospective study-[G]
S (a)NAS (b)S (c)But one study showed that the overall number of organs per donor was essentially unchanged from the baseline year.Very low
a

= No RCTs, only audit reports, surveys and medical records review.

b

= Not transferable to other population addressed because studies carried out when specialist nurses for organ donation were not in place and certain interventions were not in place, and some studies not carried out in UK and legislative rules vary in different countries

c

= Limited analyses performed

From: Appendix D, Full GRADE evidence profiles

Cover of Organ Donation for Transplantation
Organ Donation for Transplantation: Improving Donor Identification and Consent Rates for Deceased Organ Donation.
NICE Clinical Guidelines, No. 135.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

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