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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis

Review published: 2012.

Bibliographic details: Liu C, Wang QS, Wang YJ.  The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention 2012; 13(5): 2051-2055. [PubMed: 22901170]

Abstract

BACKGROUND: The cell cycle checkpoint kinase 2 (CHEK2) gene I157T variant may be associated with an increased risk of colorectal cancer, but it is unclear whether the evidence is sufficient to recommend testing for the mutation in clinical practice.

MATERIALS AND METHODS: We systematically searched PubMed, EMBASES, Elsevier and Springer for relevant articles before Apr 2012. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using a fixed-effects or random-effects models with Review Manager 5.0 software.

RESULTS: A total of seven studies including 4,029 cases and 13,844 controls based on the search criteria were included for analysis. A significant association of the CHEK2 I157T C variant with unselected CRC was found (OR=1.61, 95% CI=1.40-1.87, P<0.001). We also found a significant association with sporadic CRC (OR=1.48, 95% CI=1.23-1.77, P<0.001) and separately with familial CRC (OR=1.97, 95% CI=1.41-2.74, P<0.001).

CONCLUSION: This meta-analysis demonstrates that the CHEK2 I157T variant may be another important CRC-predisposing gene, which increases CRC risk, especially in familial CRC.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2014 University of York.

PMID: 22901170

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