Table 5Drug Combined With Lifestyle Interventions for Hypertension in Children and Adolescents

Author, year
Quality rating
Study design
Setting
Duration
NDemographicsTreatment/InterventionBlood pressure outcomes (SBP, DBP mmHg)
Berenson et al, 198358
Fair
Other publication: Frank et al, 198271
RCT
School-based
6 months
150NRADAPT Program
Group A: Propranolol 20-40 mg + chlorthalidone 6.25-12.5 mg + nutrition education and promotion of dietary modification
Group B: Hypertensive control group
Mean change from baseline, SBP:
Group A: -7.6
Group B: -3.0
Mean change from baseline, DBP:
Group A: -6.9
Group B: -3.9
Berenson et al, 199059
Fair
Continuation of Berenson et al, 198358
RCT
School-based
30 months
150Mean age 12 years
55% male
47% white
Mean SBP 117.7
Mean DBP 78.1
Same as aboveAdjusted mean difference, SBP:
Group A vs. Group B: -3.6 (SD 1.12; p<0.01)
Adjusted mean difference DBP:
Group A vs. Group B: -1.7 (SD 0.82; p<0.05)

ADAPT = A Dietary/Exercise Alteration Program Trial; BMI = body mass index; BP = blood pressure; CI = confidence interval; DASH = Dietary Approaches to Stop Hypertension; DBP = diastolic blood pressure; NR = not reported; RCT = randomized controlled trial; SBP = systolic blood pressure; SD = standard deviation.

From: 3, RESULTS

Cover of Screening for Hypertension in Children and Adolescents to Prevent Cardiovascular Disease
Screening for Hypertension in Children and Adolescents to Prevent Cardiovascular Disease: Systematic Review for the U.S. Preventive Services Task Force [Internet].
Evidence Syntheses, No. 99.
Thompson M, Dana T, Bougatsos C, et al.

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