Table 55Antidepressant medication interventions: study characteristics

Author, YearInclusion criteria (Sex and Age Group)Type of Trauma/SubgroupStudy Design and DurationComparison GroupsBaseline NumberRisk of Bias
Robert, et al., 199968Male and female thermally injured children ages 2-19 with acute stress disorder symptoms for at least 2 daysThermal injuryParallel RCT

1 week of medication nightly, burn treatment including physical rehabilitation and pain, itching, and anxiety control
G1: Imipramine
G2: Chloral hydrate
Randomized
G1: 12
G2: 13

Analyzed
G1: 12
G2: 13
Medium
Robert, et al., 200869Male and female thermally injured children ages 4-18 with acute stress symptomsThermal injuryParallel RCT

1 week of medication nightly and standard burn treatment
G1: Imipramine
G2: Fluoxetine
G3: Placebo
Randomized
G1: 21
G2: 19
G3: 22

Analyzed
G1: 20
G2: 18
G3: 22
Low
Robb, et al., 201070Male and female children ages 6-17 with PTSD from multiple traumasMultiple (sexual abuse, traumatic news, physical abuse, car and other accidents, fire or natural disaster, or witness to violence)Parallel RCT

10 weeks of medication
G1: Sertraline
G2: Placebo
Randomized
G1: 67
G2: 62

Analyzed
G1: 67
G2: 61
Low

G = group; PTSD = post-traumatic stress disorder; RCT = randomized controlled trial

From: Results

Cover of Child and Adolescent Exposure to Trauma
Child and Adolescent Exposure to Trauma: Comparative Effectiveness of Interventions Addressing Trauma Other Than Maltreatment or Family Violence [Internet].
Comparative Effectiveness Reviews, No. 107.
Forman-Hoffman V, Knauer S, McKeeman J, et al.

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