NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Thorne-Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatric and Perinatal Epidemiology 2012; 26(Supplement 1): 36-54. [PMC free article: PMC3843354] [PubMed: 22742601]
Abstract
Vitamin A (VA) deficiency during pregnancy is common in low-income countries and a growing number of intervention trials have examined the effects of supplementation during pregnancy on maternal, perinatal and infant health outcomes. We systematically reviewed the literature to identify trials isolating the effects of VA or carotenoid supplementation during pregnancy on maternal, fetal, neonatal and early infant health outcomes. Meta-analysis was used to pool effect estimates for outcomes with more than one comparable study. We used GRADE criteria to assess the quality of individual studies and the level of evidence available for each outcome. We identified 23 eligible trials of which 17 had suitable quality for inclusion in meta-analyses. VA or beta-carotene (βC) supplementation during pregnancy did not have a significant overall effect on birthweight indicators, preterm birth, stillbirth, miscarriage or fetal loss. Among HIV-positive women, supplementation was protective against low birthweight (<2.5 kg) [risk ratio (RR) = 0.79 [95% confidence interval (CI) 0.64, 0.99]], but no significant effects on preterm delivery or small-for-gestational age were observed. Pooled analysis of the results of three large randomised trials found no effects of VA supplementation on neonatal/infant mortality, or pregnancy-related maternal mortality (random-effects RR = 0.86 [0.60, 1.24]) although high heterogeneity was observed in the maternal mortality estimate (I(2) = 74%, P = 0.02). VA supplementation during pregnancy was found to improve haemoglobin levels and reduce anaemia risk (<11.0 g/dL) during pregnancy (random-effects RR = 0.81 [0.69, 0.94]), also with high heterogeneity (I(2) = 52%, P = 0.04). We found no effect of VA/βC supplementation on mother-to-child HIV transmission in pooled analysis, although some evidence suggests that it may increase transmission. There is little consistent evidence of benefit of maternal supplementation with VA or βC during pregnancy on maternal or infant mortality. While there may be beneficial effects for certain outcomes, there may also be potential for harm through increased HIV transmission in some populations.
© 2012 Blackwell Publishing Ltd.
- Review Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.[Cochrane Database Syst Rev. 2011]Review Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.Wiysonge CS, Shey M, Kongnyuy EJ, Sterne JA, Brocklehurst P. Cochrane Database Syst Rev. 2011 Jan 19; (1):CD003648. Epub 2011 Jan 19.
- Review Vitamin A supplements for reducing mother-to-child HIV transmission.[Cochrane Database Syst Rev. 2017]Review Vitamin A supplements for reducing mother-to-child HIV transmission.Wiysonge CS, Ndze VN, Kongnyuy EJ, Shey MS. Cochrane Database Syst Rev. 2017 Sep 7; 9(9):CD003648. Epub 2017 Sep 7.
- Review Vitamin A supplementation during pregnancy for maternal and newborn outcomes.[Cochrane Database Syst Rev. 2010]Review Vitamin A supplementation during pregnancy for maternal and newborn outcomes.van den Broek N, Dou L, Othman M, Neilson JP, Gates S, Gülmezoglu AM. Cochrane Database Syst Rev. 2010 Nov 10; (11):CD008666. Epub 2010 Nov 10.
- Review Antenatal dietary education and supplementation to increase energy and protein intake.[Cochrane Database Syst Rev. 2015]Review Antenatal dietary education and supplementation to increase energy and protein intake.Ota E, Hori H, Mori R, Tobe-Gai R, Farrar D. Cochrane Database Syst Rev. 2015 Jun 2; (6):CD000032. Epub 2015 Jun 2.
- Review Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.[Cochrane Database Syst Rev. 2002]Review Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.Shey WI, Brocklehurst P, Sterne JA. Cochrane Database Syst Rev. 2002; (3):CD003648.
- Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant hea...Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
Your browsing activity is empty.
Activity recording is turned off.
See more...