Table 4.3Evidence profile for active use therapy compared with no active use therapy in children with unilateral or bilateral spasticity; treatment acceptability assessment

Number of studiesNumber of participantsEffectQuality
Active use therapyNo active use therapyRelative

(95% CI)
Absolute

(95% CI)
COPM-S score at week 8 in 4-week OTHP group (range 0 to 10, change from baseline, better indicated by higher values)
1 study (Novak 2009)1112--aHigh
COPM-S score at week 8 in 8-week OTHP group (range 0 to 10, change from baseline, better indicated by higher values)
1 study (Novak 2009)1212--bHigh
COPM-S score at week 8 in 4-week OTHP versus 8-week OTHP groups (better indicated by higher values)
1 study (Novak 2009)1212c--dModerate
COPM-S score at week 9 (range 0 to 10, change from baseline, better indicated by higher values)
1 study (Aarts 2010)28e22f--gHigh
COPM-S score at week 17 (range 0 to 10, change from baseline, better indicated by higher values)
1 study (Aarts 2010)28h22i-MD 2.00 higher (1.20 to 2.80 higher)*High

CI confidence interval, COPM-P Canadian Occupational Performance Measure – Performance, COPM-S Canadian Occupational Performance Measure – Satisfaction, MD mean difference, OTHP Occupational Therapy Home Programme, P probability, RR relative risk, SD standard deviation

*

Calculated by the NCC-WCH

a

Results for comparison of 4-week OTHP versus no programme reported as an effect size of 2.5 (95% CI 0.8 to 4.3) P = 0.01

b

Results for comparison of 8-week OTHP versus no programme reported as an effect size of 1.5 (95% CI 0.3 to 2.6) P = 0.01

c

Comparison is 4-week OTHP group versus 8-week OTHP group, not to no-programme group

d

Results for comparison of 4-week OTHP versus 8-week OTHP reported as an effect size of 0.8 (95% CI -1.1 to 2.8) P = 0.40

e

Change from baseline at week 9 mean (SD) = 3.7 (1.6)

f

Change from baseline at week 9 mean (SD) = 1.4 (1.1)

g

Mean difference reported as 2.2 (95% CI 1.51 to 2.86) effect size reported as 1.32

h

Change from baseline at week 17 mean (SD) = 3.6 (1.6)

i

Change from baseline at week 17 mean (SD) = 1.6 (1.3)

See the complete GRADE Table K.4.3 which accompanies this abbreviated version.

From: 4, Physical therapy (physiotherapy and/or occupational therapy)

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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