Table K.8.18Evidence profile for continuous pump administered intrathecal baclofen follow up; hip displacement assessment

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsContinuous pump-administered intrathecal baclofen therapy (CITB)Usual careRelative (95% CI)Absolute (95% CI)
Absolute migration percentage at 12 months in children under 8 years old (better indicated by lower values)
1 study (Krach 2004)observational studyserious 1,2no serious inconsistencyno serious indirectnessserious3none11 (22 hips)4--5-5Very low
Absolute migration percentage at 12 months in children 8 to 18 years old (better indicated by lower values)
1 study (Krach 2004)observational studyserious 1,2no serious inconsistencyno serious indirectnessserious3none17 (34 hips)6--5-5Very low

CI confidence interval

1

Pre-post treatment data

2

The pharmaceutical company providing the pump and the drug baclofen also provided some support for data collection and analysis, including assisting with statistical analysis and reviewing the manuscript

3

Total population less than 400, 95% confidence interval not calculable

4

Mean 0.0 standard deviation (SD) (8.4) p<0.05 compared to baseline

5

No statistical comparison was given across groups

6

Mean 1.2 SD (12.8) p<0.05 compared to baseline

From: Appendix K, GRADE tables

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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