Table 8.2Evidence profile for C-reactive protein in babies about to start antibiotic treatment

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
CRP ≥ 2.5 mg/l in the prediction of infection within 12 hours of birth, using blood culture or clinical infection as reference standard
1 (Resch 2003)686996170.3Moderate
CRP ≥ 8 mg/l in the prediction of infection within 12 hours of birth, using blood culture or clinical infection as reference standard
1 (Resch 2003)6849100NC0.5Moderate
CRP > 8 mg/l in the prediction of infection in the first week of birth, using culture of bacteria from blood, CSF or urine as reference standard
1 (Philip 1980)376478630.6Moderate
CRP > 10 mg/l in the prediction of infection within the first 3 days of life, using blood culture or clinical infection as reference standard
1996/1997 data
1 (Franz 2001)37834 (23 to 47)95 (92 to 97)8 (4 to 14)0.7
(0.6 to 0.8)
High
1997/1998 data
1 (Franz 2001)33128 (20 to 38)98 (94 to 100)12 (5 to 30)0.7
(0.7 to 0.8)
High
CRP > 10 mg/l at presentation in the prediction of infection within the first 3 days of life
Using proven sepsis as reference standard
1 (Benitz 1998)100235 (30 to 40)90 (88 to 91)4 (1 to 8)0.7
(0.4 to 1.4)
High
Using either proven or probable sepsis as reference standard
1 (Benitz 1998)100239 (30 to 49)93 (91 to 94)5 (3 to 8)0.7
(0.5 to 0.9)
High
CRP > 10 mg/l in the prediction of infection within 10 days of birth, using blood culture and/or clinical diagnosis of infection as reference standard
1 (Franz 1999)16228 (16 to 43)97 (92 to 99)90.7Moderate

CRP C-reactive protein, NC not calculable

See the complete GRADE Table J 8.2

From: 8, Investigations before starting antibiotics in the baby

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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