Table 10.2Evidence profile for a 2-day course of antibiotics (probably ampicillin plus gentamicin) versus a 4-day course of the same antibiotics in babies who developed pneumonia within 54 hours of birth and whose respiratory signs resolved within 36 hours of antibiotic treatment; all the babies had received intramuscular benzylpenicillin within 1 hour of birth as part of routine practice to prevent group B streptococcal infectiona

Number of studiesNumber of babiesEffectQuality
2-day course of antibiotics4-day course of antibioticsRelative (95% confidence interval)Absolute (95% confidence interval)
Relapse rate
1 (Engle 2003)3/14
(21%)
0/12
(0%)
RR 6.07 (0.34 to 106.85)*203 more per 1000 (from 26 fewer to 4234 more)Low

RR relative risk

*

Calculated by the NCC-WCH technical team from data reported in the article

a

The trial was stopped early (to avoid harm) because of the relapse rate in the 2-day treatment arm

See the complete GRADE Table J 10.2

From: 10, Duration of antibiotic treatment

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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