Table 10.1Evidence profile for a 4-day course of ampicillin plus gentamicin versus a 7-day course in babies who developed pneumonia within 75 hours of birth and whose respiratory signs resolved within 48 hours of antibiotic treatment; all the babies had received intramuscular benzylpenicillin within 1 hour of birth as part of routine practice to prevent group B streptococcal infection

Number of studiesNumber of babiesEffectQuality
4-day course of antibiotics7-day course of antibioticsRelative (95% confidence interval)Absolute (95% confidence interval)
Cure rate (%)
1 (Engle 2000)3538≥92% in both groups
(NR)
NCLow
Duration of hospital stay (mean and standard deviation in days)
1 (Engle 2000)35386.0 (SD 1.3) versus
8.1 (SD 1.4)
(NR)
P<0.0001
2.1 days less (NR)Low

NC not calculable, NR not reported, P probability, SD standard deviation

See the complete GRADE Table J 10.1

From: 10, Duration of antibiotic treatment

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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