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National Collaborating Centre for Women's and Children's Health (UK). Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection. London: RCOG Press; 2012 Aug. (NICE Clinical Guidelines, No. 149.)

Appendix ESearch strategies

Chapter 6 Intrapartum antibiotics

Review question. What is the effectiveness of intrapartum antibiotic prophylaxis in the prevention of early-onset neonatal infection (compared to no treatment)?

Two search strategies were used for the above review question, the first was designed to identify randomised controlled trials (RCTs) and systematic reviews of RCTs. The second was designed to identify pharmacokinetic and pharmacodynamic studies. In each case, a single search was conducted to cover all the antibiotic treatment review questions (intrapartum antibiotics, routine antibiotics after birth, antibiotics for suspected infection, and optimal duration of antibiotics – see Chapters 7, 9 and 10, respectively).

Chapter 7 Routine antibiotics after birth

Review question. In babies with maternal risk factors for early-onset neonatal infection is routine administration of antibiotics to the baby effective in preventing early-onset neonatal infection?

The search strategies for this review question are presented under the question on intrapartum antibiotics (see Chapter 6).

Chapter 8 Investigations before starting antibiotics in the baby

Review questions. What investigations of asymptomatic babies after birth are useful in identifying those who should/not be treated for early-onset neonatal infection or determining the treatment strategy?
What investigations should be performed prior to commencing treatment in: babies with symptoms and babies with risk factors without symptoms?

A single search was conducted to cover both review questions.

Database(s): Ovid MEDLINE(R) 1950 to November Week 1 2010

Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations November 15, 2010

Database(s): EBM Reviews - Cochrane Central Register of Controlled Trials 4th Quarter 2010

Database(s): CDSR, DARE

Database(s): EMBASE 1980 to 2010 Week 45

Chapter 9 Antibiotics for suspected infection

Review question. What is the optimal antibiotic treatment regimen for suspected early-onset neonatal infection?

The search strategies for this review question are presented under the question on intrapartum antibiotics (see Chapter 6).

Chapter 10 Duration of antibiotic treatment

Review question. What is the optimal duration (or course length) of antibiotics for babies: with confirmed early-onset neonatal infection (bacterial cause identified), with presumed symptomatic infection but no bacterial cause identified, with initial clinical suspicion of infection but no ongoing clinical concerns and all investigations normal, and asymptomatic babies receiving prophylactic treatment?

The search strategies for this review question are presented under the question on intrapartum antibiotics (see Chapter 6).

Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.

NICE (National Institute for Health and Care Excellence)

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