Table 6.28Evidence profile for clindamycin compared with placebo for women with preterm labour

Number of studiesNumber of babies/womenEffectQuality
ClindamycinPlaceboRelative (95% confidence interval)Absolute (95% confidence interval)
Newborn treatment to rule out sepsis
1(McGregor 199116/53
RR 1.08 (0.59 to 1.97)*22 more per 1000 (from 115 fewer to 272 more)Moderate
1(McGregor 19911/51
RR 0.33 (0.04 to 3.04)*40 fewer per 1000 (from 58 fewer to 122 more)Low
Neonatal deaths
1(McGregor 1991)2/53
RR 4.72 (0.23 to 96.01)*NCModerate
Gestational age at birth in weeks (SD) : (better indicated by higher values)
1(McGregor 19915350-MD 0.5 higher (0.78 lower to 1.78 higher)*Moderate
Postpartum endometritis
1(McGregor 1991)4/36
RR 0.97 (0.26 to 3.59)*3 fewer per 1000 (from 85 fewer to 296 more)Low
Side effects reported by mother
1(McGregor 199115/53
RR 0.88 (0.49 to 1.59)*38 fewer per 1000 (from 163 fewer to 189 more)Moderate

MD mean difference, NC not calculable, RR relative risk


Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.28

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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