Table 6.16Evidence profile for ampicillin-sulbactam followed by amoxicillin-clavulanic acid or ampicillin followed by amoxicillin compared with placebo in women with preterm prelabour rupture of membranes

Number of studiesNumber of babies/womenEffectQuality
Ampicillin- sulbactam followed by amoxicillin- clavulanic acid or ampicillin followed by amoxicillinPlaceboRelative (95% confidence interval)Absolute (95% confidence interval)
Confirmed or suspected neonatal sepsis
1 (Lovett 1997)6/75
RR 0.49 (0.17 to 1.43)*83 fewer per 1000 (from 135 fewer to 70 more)*Low
Fetal or postnatal mortality
1 (Lovett 1997)0/75
RR 0.07 (0.00 to 1.35)*75 fewer per 1000 (from 81 fewer to 28 more)*Moderate

RR relative risk


Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.16

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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