Table 6.15Evidence profile for ampicillin and erythromycin followed by amoxicillin and erythromycin compared with placebo in women with preterm prelabour rupture of membranes

Number of studiesNumber of babies/womenEffectQuality
Ampicillin and erythromycin followed by amoxicillin and erythromycinPlaceboRelative (95% confidence interval)Absolute (95% confidence interval)
Early-onset neonatal sepsis (within 72 hours of birth)
1 (Mercer 1997)16/299
RR 0.83 (0.44 to 1.58)*11 fewer per 1000 (from 36 fewer to 37 more)*Low
Early-onset pneumonia (within 72 hours of birth)
1 (Mercer 1997)5/299
RR 0.43 (0.16 to 1.22)*22 fewer per 1000 (from 32 fewer to 8 more)*Low
Necrotising enterocolitis (stage 2 or 3)
1 (Mercer 1997)7/299
RR 0.41 (0.17 to 0.96)*34 fewer per 1000 (from 2 fewer to 48 more)*Low
Fetal or postnatal mortality
1 (Mercer 1997)19/299
RR 1.1 (0.59 to 2.06)*6 more per 1000 (from 24 fewer to 61 more)*Low

RR relative risk


Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.15

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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