Table 5.5Evidence profile for diagnostic test accuracy of prolonged preterm prelabour rupture of membranes (> 24 hours) for predicting early-onset neonatal infection (in the first 7 days of life) in extremely premature or low birthweight babies (< 28 weeks’ gestation at birth or birthweight < 1000g)

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
Prolonged preterm prelabour rupture of membranes
(Ronnestad 2005)
(22.4 to 57.5)*
(73.1 to 81.1)*
(1.09 to 2.80)*
(0.58 to 1.05)*

Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 5.5

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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