Table 5.16Evidence profile for diagnostic test accuracy of individual clinical signs for predicting blood-culture-positive infection in babies with suspected sepsis in the first 28 days of life

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
Increased oxygen need
1 (Ohlin 2010)40121.7
(12.8 to 30.6)*
76.4
(71.8 to 81.1)*
0.92
(0.58 to 1.45)*
1.02
(0.90 to 1.17)*
Low
Apnoea
1 (Ohlin 2010)40149.4
(38.6 to 60.2)*
87.4
(83.8 to 91.1)*
3.93
(2.73 to 5.64)*
0.58
(0.47 to 0.72)*
Low
Tachypnoea
1 (Ohlin 2010)40130.1
(20.3 to 40.0)*
64.2
(58.9 to 69.4)*
0.84
(0.59 to 1.20)*
1.09
(0.93 to 1.28)*
Low
Bradycardia
1 (Ohlin 2010)40138.6
(28.1 to 49.0)*
88.4
(84.8 to 91.9)*
3.31
(2.21 to 4.98)*
0.70
(0.58 to 0.83)*
Low
Hypotension or impaired peripheral circulation
1 (Ohlin 2010)40139.8
(29.2 to 50.3)*
78.9
(74.5 to 83.4)*
1.89
(1.34 to 2.65)*
0.76
(0.64 to 0.92)*
Low
Irritability or seizures
1 (Ohlin 2010)40127.7
(18.1 to 37.3)*
76.1
(71.4 to 80.8)*
1.16
(0.78 to 1.73)*
0.95
(0.82 to 1.10)*
Low
Feeding intolerance
1 (Ohlin 2010)40125.3
(16.0 to 34.7)*
84.9
(81.0 to 88.8)*
1.68
(1.07 to 2.63)*
0.88
(0.77 to 1.01)*
Low
Distended abdomen
1 (Ohlin 2010)40114.5
(6.89 to 22.0)*
98.4
(97.1 to 99.8)*
9.20
(3.33 to 25.4)*
0.87
(0.79 to 0.95)*
Low
Patent ductus arteriosus
1 (Ohlin 2010)4014.82
(0.21 to 9.43)*
97.5
(95.8 to 99.2)*
1.92
(0.59 to 6.21)*
0.98
(0.93 to 1.03)*
Low
*

Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 5.16

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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