Table 4-7Pharmacological prophylaxis – information and prices from the British National Formulary

DrugDoseInjections per dayDrug cost per day
UFH5000 units subcutaneous every 8 hours3£2.76
LMWH (Medical)Average of:
Dalteparin 5000 units subcutaneous daily
Enoxaparin 4000 units subcutaneous daily
1£3.51
LMWH (General Surgery)Average of high dose (see dose for major orthopaedic surgery) and moderate dose:
Bemiparin 2500 units subcutaneous daily
Dalteparin 2500 units subcutaneous daily
Enoxaparin 2000 units subcutaneous daily
Tinziparin 3500 units subcutaneous daily
1£3.34
LMWH (Major orthopaedic surgery)Average of:
Bemiparin 3500 units subcutaneous daily
Dalteparin 5000 units subcutaneous daily
Enoxaparin 4000 units subcutaneous daily
Tinziparin 4500 units subcutaneous daily
1£3.84
Fondaparinux sodium2.5mg subcutaneous daily1£6.66
Vitamin K antagonist (Warfarin)Dose is adjustable. [Assumed average of 4mg per day]N/A£0.04
Aspirin (High dose)Aspirin is not licensed specifically for thromboprophylaxis [A typical aspirin dose from the RCTs in our review is 1000mg]N/A£0.19
Aspirin (Low dose)Aspirin is not licensed specifically for thromboprophylaxis [A typical aspirin dose from the RCTs in our review is 300mg]N/A£0.06
Dabigatran220mg dailyN/A£4.20
Rivaroxaban10mg dailyN/A£4.50

From: 4, Development of cost-effectiveness model

Cover of Venous Thromboembolism
Venous Thromboembolism: Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital.
NICE Clinical Guidelines, No. 92.
National Clinical Guideline Centre – Acute and Chronic Conditions (UK).
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