Table DSummary of strength of evidence for the development of akathisia with the addition of anticholinergics to metoclopramide and phenothiazine (Key Question 4)

OutcomeComparison (# Studies)SOESummary
AkathisiaMetoclopramide + anticholinergic vs. phenothiazine + anticholinergic (1 RCT)InsufficientNo significant difference between groups
(OR = 1.50; 95% CI, 0.24 to 9.52)
Prochlorperazine + diphenhydramine vs. prochlorperazine (1 RCT)InsufficientNo significant difference
(OR = 0.46; 95% CI, 0.17 to 1.28)

CI = confidence interval; OR = odds ratio; RCT = randomized controlled trial; SOE = strength of evidence

From: Executive Summary

Cover of Acute Migraine Treatment in Emergency Settings
Acute Migraine Treatment in Emergency Settings [Internet].
Comparative Effectiveness Reviews, No. 84.
Sumamo Schellenberg E, Dryden DM, Pasichnyk D, et al.

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