Table COverall strength of evidence for iron trials for the treatment of secondary RLS

OutcomeNumber of TrialsNSummary Statistics
[95% CI]
Risk of BiasDirectnessPrecisionConsistencyStrength of Evidence
IRLS responders (≥50% score reduction)*160RR
1.85 [1.07 to 3.18]
LowDirectPreciseUnknownLow*
IRLS total score: mean change from baseline278WMD
−5.25 [−12.44 to 1.95]
LowDirectImpreciseInconsistentLow

CI = confidence interval; IRLS = International Restless Legs Syndrome Study Group Rating Scale; RR = risk ratio; WMD = weighted mean difference

*

Post hoc analysis

From: Executive Summary

Cover of Treatment for Restless Legs Syndrome
Treatment for Restless Legs Syndrome [Internet].
Comparative Effectiveness Reviews, No. 86.
Wilt TJ, MacDonald R, Ouellette J, et al.

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