Appendix F. Table 6International Restless Legs Study Group Rating (IRLS) scores for nonpharmacologic studies

Author, yearStudy Duration (weeks)Intervention/Comparator (daily dose) (n)IRLS score (SD) BaselineIRLS score (SD), After treatmentBefore/After Difference (SD/SE)Treatment versus Control, Difference [95% CI]p-value
Mitchell, 2011364Near-infrared (17)24.5 (5.3)--−13.4 (8.1)−9.00 [−13.21 to −4.79]0.001
Sham (17)23.6 (6.9)--−4.4 (3.6)
Cuellar, 2009378Valerian (800 mg) (24)23.0 (5.9)--3.4 (9.4)−1.30 [−7.68, 5.08]0.69
Placebo (NR) (24)24.0 (8.0)--4.7 (10.4)
Lettieri, 2008334Compression (21)20.3 (5.9)8.4 (3.4)--−5.70 [−8.21, −3.19]< 0.05
Sham (14)19.0 (5.2)14.1 (3.9)--
Aukerman, 20063412Exercise (11)20.6 (6.4)12.1 (5.6)--−9.40 [−13.86, −4.94]< 0.05
Control (17)22.5 (6.4)21.5 (6.3)--

From: Appendix F, Outcomes Tables

Cover of Treatment for Restless Legs Syndrome
Treatment for Restless Legs Syndrome [Internet].
Comparative Effectiveness Reviews, No. 86.
Wilt TJ, MacDonald R, Ouellette J, et al.

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